Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia

2014–2017

Eric P.F. Chow, Sepehr N. Tabrizi, Christopher K. Fairley, Rebecca Wigan, Dorothy A. Machalek, David G. Regan, Jane S. Hocking, Suzanne M. Garland, Alyssa M. Cornall, Steph Atchison, Catriona S. Bradshaw, Anna McNulty, Louise Owen, Lewis Marshall, Darren B. Russell, John M. Kaldor, Marcus Y. Chen

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background: Australia introduced a school-based human papillomavirus (HPV) vaccination program for females aged 12–13 years in 2007, with a three-year catch-up to age 26; and for boys aged 12–13 from 2013, with a two-year catch-up to age 15. This study aimed to compare the prevalence of penile HPV between teenage heterosexual males in cohorts eligible or non-eligible for the school-based male vaccination program. Methods: Between 2014 and 2017, sexually active heterosexual males aged 17–19 were recruited from sexual health centres and community sources across Australia. Males provided a self-collected penile swab for 37 HPV genotypes using Roche Linear Array and completed a questionnaire. We calculated adjusted prevalence ratios (aPR) of HPV between males in two periods: 2014–2015 (preceding implementation of school-based male vaccination) and 2016–2017 (eligible for school-based male vaccination). Self-reported vaccine doses were confirmed with doses reported to the National HPV Vaccination Program Register. Results: Overall, 152 males were recruited in 2014–2015 and 146 in 2016–2017. Numbers of female sex partners and condom use did not differ between the two periods. The prevalence of quadrivalent vaccine-preventable [4vHPV] genotypes (6/11/16/18) was low in both periods (2.6% [2014–15] versus 0.7% [2016–17]; p = 0.371; aPR 0.28 [95% CI: 0.03–2.62]). Compared with men in 2014–2015, men in 2016–2017 had a lower prevalence of any of the 37 HPV genotypes tested (21.7% versus 11.6%; aPR 0.62 [95% CI: 0.36–1.07]) and any of the 13 high-risk genotypes tested (15.8% versus 7.5%; aPR 0.59 [95% CI: 0.30–1.19]). Prevalence of low-risk HPV genotypes did not differ between the two periods. Of the males recruited in 2016–2017, 55% had received ≥1 vaccine dose. Conclusion: The prevalence of 4vHPV genotypes among teenage heterosexual males in both cohorts was low, presumably due to herd protection from the female-only vaccination program. Further studies are required to determine the impact of universal HPV vaccination on HPV prevalence in males.

Original languageEnglish
Pages (from-to)6907-6914
Number of pages8
JournalVaccine
Volume37
Issue number46
DOIs
Publication statusPublished - 31 Oct 2019

Keywords

  • Australia
  • Control
  • Heterosexual
  • HPV
  • Human papillomavirus
  • Male
  • Prevention
  • Vaccination
  • Vaccine

Cite this

Chow, Eric P.F. ; Tabrizi, Sepehr N. ; Fairley, Christopher K. ; Wigan, Rebecca ; Machalek, Dorothy A. ; Regan, David G. ; Hocking, Jane S. ; Garland, Suzanne M. ; Cornall, Alyssa M. ; Atchison, Steph ; Bradshaw, Catriona S. ; McNulty, Anna ; Owen, Louise ; Marshall, Lewis ; Russell, Darren B. ; Kaldor, John M. ; Chen, Marcus Y. / Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia : 2014–2017. In: Vaccine. 2019 ; Vol. 37, No. 46. pp. 6907-6914.
@article{68435146cf7c4859ab926c67741d9eb7,
title = "Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia: 2014–2017",
abstract = "Background: Australia introduced a school-based human papillomavirus (HPV) vaccination program for females aged 12–13 years in 2007, with a three-year catch-up to age 26; and for boys aged 12–13 from 2013, with a two-year catch-up to age 15. This study aimed to compare the prevalence of penile HPV between teenage heterosexual males in cohorts eligible or non-eligible for the school-based male vaccination program. Methods: Between 2014 and 2017, sexually active heterosexual males aged 17–19 were recruited from sexual health centres and community sources across Australia. Males provided a self-collected penile swab for 37 HPV genotypes using Roche Linear Array and completed a questionnaire. We calculated adjusted prevalence ratios (aPR) of HPV between males in two periods: 2014–2015 (preceding implementation of school-based male vaccination) and 2016–2017 (eligible for school-based male vaccination). Self-reported vaccine doses were confirmed with doses reported to the National HPV Vaccination Program Register. Results: Overall, 152 males were recruited in 2014–2015 and 146 in 2016–2017. Numbers of female sex partners and condom use did not differ between the two periods. The prevalence of quadrivalent vaccine-preventable [4vHPV] genotypes (6/11/16/18) was low in both periods (2.6{\%} [2014–15] versus 0.7{\%} [2016–17]; p = 0.371; aPR 0.28 [95{\%} CI: 0.03–2.62]). Compared with men in 2014–2015, men in 2016–2017 had a lower prevalence of any of the 37 HPV genotypes tested (21.7{\%} versus 11.6{\%}; aPR 0.62 [95{\%} CI: 0.36–1.07]) and any of the 13 high-risk genotypes tested (15.8{\%} versus 7.5{\%}; aPR 0.59 [95{\%} CI: 0.30–1.19]). Prevalence of low-risk HPV genotypes did not differ between the two periods. Of the males recruited in 2016–2017, 55{\%} had received ≥1 vaccine dose. Conclusion: The prevalence of 4vHPV genotypes among teenage heterosexual males in both cohorts was low, presumably due to herd protection from the female-only vaccination program. Further studies are required to determine the impact of universal HPV vaccination on HPV prevalence in males.",
keywords = "Australia, Control, Heterosexual, HPV, Human papillomavirus, Male, Prevention, Vaccination, Vaccine",
author = "Chow, {Eric P.F.} and Tabrizi, {Sepehr N.} and Fairley, {Christopher K.} and Rebecca Wigan and Machalek, {Dorothy A.} and Regan, {David G.} and Hocking, {Jane S.} and Garland, {Suzanne M.} and Cornall, {Alyssa M.} and Steph Atchison and Bradshaw, {Catriona S.} and Anna McNulty and Louise Owen and Lewis Marshall and Russell, {Darren B.} and Kaldor, {John M.} and Chen, {Marcus Y.}",
year = "2019",
month = "10",
day = "31",
doi = "10.1016/j.vaccine.2019.09.052",
language = "English",
volume = "37",
pages = "6907--6914",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "46",

}

Chow, EPF, Tabrizi, SN, Fairley, CK, Wigan, R, Machalek, DA, Regan, DG, Hocking, JS, Garland, SM, Cornall, AM, Atchison, S, Bradshaw, CS, McNulty, A, Owen, L, Marshall, L, Russell, DB, Kaldor, JM & Chen, MY 2019, 'Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia: 2014–2017', Vaccine, vol. 37, no. 46, pp. 6907-6914. https://doi.org/10.1016/j.vaccine.2019.09.052

Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia : 2014–2017. / Chow, Eric P.F.; Tabrizi, Sepehr N.; Fairley, Christopher K.; Wigan, Rebecca; Machalek, Dorothy A.; Regan, David G.; Hocking, Jane S.; Garland, Suzanne M.; Cornall, Alyssa M.; Atchison, Steph; Bradshaw, Catriona S.; McNulty, Anna; Owen, Louise; Marshall, Lewis; Russell, Darren B.; Kaldor, John M.; Chen, Marcus Y.

In: Vaccine, Vol. 37, No. 46, 31.10.2019, p. 6907-6914.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prevalence of human papillomavirus in teenage heterosexual males following the implementation of female and male school-based vaccination in Australia

T2 - 2014–2017

AU - Chow, Eric P.F.

AU - Tabrizi, Sepehr N.

AU - Fairley, Christopher K.

AU - Wigan, Rebecca

AU - Machalek, Dorothy A.

AU - Regan, David G.

AU - Hocking, Jane S.

AU - Garland, Suzanne M.

AU - Cornall, Alyssa M.

AU - Atchison, Steph

AU - Bradshaw, Catriona S.

AU - McNulty, Anna

AU - Owen, Louise

AU - Marshall, Lewis

AU - Russell, Darren B.

AU - Kaldor, John M.

AU - Chen, Marcus Y.

PY - 2019/10/31

Y1 - 2019/10/31

N2 - Background: Australia introduced a school-based human papillomavirus (HPV) vaccination program for females aged 12–13 years in 2007, with a three-year catch-up to age 26; and for boys aged 12–13 from 2013, with a two-year catch-up to age 15. This study aimed to compare the prevalence of penile HPV between teenage heterosexual males in cohorts eligible or non-eligible for the school-based male vaccination program. Methods: Between 2014 and 2017, sexually active heterosexual males aged 17–19 were recruited from sexual health centres and community sources across Australia. Males provided a self-collected penile swab for 37 HPV genotypes using Roche Linear Array and completed a questionnaire. We calculated adjusted prevalence ratios (aPR) of HPV between males in two periods: 2014–2015 (preceding implementation of school-based male vaccination) and 2016–2017 (eligible for school-based male vaccination). Self-reported vaccine doses were confirmed with doses reported to the National HPV Vaccination Program Register. Results: Overall, 152 males were recruited in 2014–2015 and 146 in 2016–2017. Numbers of female sex partners and condom use did not differ between the two periods. The prevalence of quadrivalent vaccine-preventable [4vHPV] genotypes (6/11/16/18) was low in both periods (2.6% [2014–15] versus 0.7% [2016–17]; p = 0.371; aPR 0.28 [95% CI: 0.03–2.62]). Compared with men in 2014–2015, men in 2016–2017 had a lower prevalence of any of the 37 HPV genotypes tested (21.7% versus 11.6%; aPR 0.62 [95% CI: 0.36–1.07]) and any of the 13 high-risk genotypes tested (15.8% versus 7.5%; aPR 0.59 [95% CI: 0.30–1.19]). Prevalence of low-risk HPV genotypes did not differ between the two periods. Of the males recruited in 2016–2017, 55% had received ≥1 vaccine dose. Conclusion: The prevalence of 4vHPV genotypes among teenage heterosexual males in both cohorts was low, presumably due to herd protection from the female-only vaccination program. Further studies are required to determine the impact of universal HPV vaccination on HPV prevalence in males.

AB - Background: Australia introduced a school-based human papillomavirus (HPV) vaccination program for females aged 12–13 years in 2007, with a three-year catch-up to age 26; and for boys aged 12–13 from 2013, with a two-year catch-up to age 15. This study aimed to compare the prevalence of penile HPV between teenage heterosexual males in cohorts eligible or non-eligible for the school-based male vaccination program. Methods: Between 2014 and 2017, sexually active heterosexual males aged 17–19 were recruited from sexual health centres and community sources across Australia. Males provided a self-collected penile swab for 37 HPV genotypes using Roche Linear Array and completed a questionnaire. We calculated adjusted prevalence ratios (aPR) of HPV between males in two periods: 2014–2015 (preceding implementation of school-based male vaccination) and 2016–2017 (eligible for school-based male vaccination). Self-reported vaccine doses were confirmed with doses reported to the National HPV Vaccination Program Register. Results: Overall, 152 males were recruited in 2014–2015 and 146 in 2016–2017. Numbers of female sex partners and condom use did not differ between the two periods. The prevalence of quadrivalent vaccine-preventable [4vHPV] genotypes (6/11/16/18) was low in both periods (2.6% [2014–15] versus 0.7% [2016–17]; p = 0.371; aPR 0.28 [95% CI: 0.03–2.62]). Compared with men in 2014–2015, men in 2016–2017 had a lower prevalence of any of the 37 HPV genotypes tested (21.7% versus 11.6%; aPR 0.62 [95% CI: 0.36–1.07]) and any of the 13 high-risk genotypes tested (15.8% versus 7.5%; aPR 0.59 [95% CI: 0.30–1.19]). Prevalence of low-risk HPV genotypes did not differ between the two periods. Of the males recruited in 2016–2017, 55% had received ≥1 vaccine dose. Conclusion: The prevalence of 4vHPV genotypes among teenage heterosexual males in both cohorts was low, presumably due to herd protection from the female-only vaccination program. Further studies are required to determine the impact of universal HPV vaccination on HPV prevalence in males.

KW - Australia

KW - Control

KW - Heterosexual

KW - HPV

KW - Human papillomavirus

KW - Male

KW - Prevention

KW - Vaccination

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=85072614561&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2019.09.052

DO - 10.1016/j.vaccine.2019.09.052

M3 - Article

VL - 37

SP - 6907

EP - 6914

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 46

ER -