Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China

A systematic review and meta-analysis

Xiaomeng Ma, Qian Wang, Jason J. Ong, Christopher K. Fairley, Shu Su, Peng Peng, Jun Jing, Linhong Wang, Nyi Nyi Soe, Feng Cheng, Lei Zhang

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Objective: Human papillomavirus (HPV) infection causes multiple cancers in both women and men. In China, both HPV vaccination and cervical cancer screening coverages are low. We aim to investigate the temporal and geographical trends of HPV DNA prevalence in heterosexual men, women, men who have sex with men (MSM) and people living with HIV (PLHIV) in China. Methods: We conducted a systematic review, collecting publications in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Data from January 2000 to May 2017. A total of 247 studies were selected for this meta-analysis to estimate pooled HPV prevalence, incidence of cervical cancer and risk of infection for subgroups. Meta-regression was applied to identify contributing factors to prevalence heterogeneities. Results: The national HPV prevalence was 15.6% (95% CI (14.4% to 16.9%)) in women with normal cervical cytology, and Central China had the highest prevalence (20.5% (15.2% to 25.8%)). HPV prevalence in heterosexual men (14.5% (11.3% to 17.7%)) was comparable with that of women (OR=1.09 (0.98 to 1.17)), but HPV prevalence in MSM (59.9% (52.2% to 67.6%)) was significantly higher than that in heterosexual men (OR=8.81 (8.01 to 9.69)). HIV-positive women (45.0% (38.4% to 51.6%)) and HIV-positive MSM (87.5% (82.3% to 90.9%)) had 4.67 (3.61 to 6.03) and 6.46 (5.20 to 8.02) times higher risk of HPV infection than their HIV negative counterparts. Conclusion: HPV infection is prevalent in China, particularly in Central China, in comparison with the global level and neighbouring countries. Targeted HPV vaccination for women, MSM and PLHIV and scale-up of cervical screening for women are priorities in curbing the HPV epidemic in China.

Original languageEnglish
Pages (from-to)434-442
Number of pages9
JournalSexually Transmitted Infections
Volume94
Issue number6
DOIs
Publication statusPublished - 24 May 2018

Keywords

  • gay men
  • Hiv
  • Hpv
  • meta-analysis
  • women

Cite this

Ma, Xiaomeng ; Wang, Qian ; Ong, Jason J. ; Fairley, Christopher K. ; Su, Shu ; Peng, Peng ; Jing, Jun ; Wang, Linhong ; Soe, Nyi Nyi ; Cheng, Feng ; Zhang, Lei. / Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China : A systematic review and meta-analysis. In: Sexually Transmitted Infections. 2018 ; Vol. 94, No. 6. pp. 434-442.
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title = "Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China: A systematic review and meta-analysis",
abstract = "Objective: Human papillomavirus (HPV) infection causes multiple cancers in both women and men. In China, both HPV vaccination and cervical cancer screening coverages are low. We aim to investigate the temporal and geographical trends of HPV DNA prevalence in heterosexual men, women, men who have sex with men (MSM) and people living with HIV (PLHIV) in China. Methods: We conducted a systematic review, collecting publications in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Data from January 2000 to May 2017. A total of 247 studies were selected for this meta-analysis to estimate pooled HPV prevalence, incidence of cervical cancer and risk of infection for subgroups. Meta-regression was applied to identify contributing factors to prevalence heterogeneities. Results: The national HPV prevalence was 15.6{\%} (95{\%} CI (14.4{\%} to 16.9{\%})) in women with normal cervical cytology, and Central China had the highest prevalence (20.5{\%} (15.2{\%} to 25.8{\%})). HPV prevalence in heterosexual men (14.5{\%} (11.3{\%} to 17.7{\%})) was comparable with that of women (OR=1.09 (0.98 to 1.17)), but HPV prevalence in MSM (59.9{\%} (52.2{\%} to 67.6{\%})) was significantly higher than that in heterosexual men (OR=8.81 (8.01 to 9.69)). HIV-positive women (45.0{\%} (38.4{\%} to 51.6{\%})) and HIV-positive MSM (87.5{\%} (82.3{\%} to 90.9{\%})) had 4.67 (3.61 to 6.03) and 6.46 (5.20 to 8.02) times higher risk of HPV infection than their HIV negative counterparts. Conclusion: HPV infection is prevalent in China, particularly in Central China, in comparison with the global level and neighbouring countries. Targeted HPV vaccination for women, MSM and PLHIV and scale-up of cervical screening for women are priorities in curbing the HPV epidemic in China.",
keywords = "gay men, Hiv, Hpv, meta-analysis, women",
author = "Xiaomeng Ma and Qian Wang and Ong, {Jason J.} and Fairley, {Christopher K.} and Shu Su and Peng Peng and Jun Jing and Linhong Wang and Soe, {Nyi Nyi} and Feng Cheng and Lei Zhang",
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Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China : A systematic review and meta-analysis. / Ma, Xiaomeng; Wang, Qian; Ong, Jason J.; Fairley, Christopher K.; Su, Shu; Peng, Peng; Jing, Jun; Wang, Linhong; Soe, Nyi Nyi; Cheng, Feng; Zhang, Lei.

In: Sexually Transmitted Infections, Vol. 94, No. 6, 24.05.2018, p. 434-442.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Prevalence of human papillomavirus by geographical regions, sexual orientation and HIV status in China

T2 - A systematic review and meta-analysis

AU - Ma, Xiaomeng

AU - Wang, Qian

AU - Ong, Jason J.

AU - Fairley, Christopher K.

AU - Su, Shu

AU - Peng, Peng

AU - Jing, Jun

AU - Wang, Linhong

AU - Soe, Nyi Nyi

AU - Cheng, Feng

AU - Zhang, Lei

PY - 2018/5/24

Y1 - 2018/5/24

N2 - Objective: Human papillomavirus (HPV) infection causes multiple cancers in both women and men. In China, both HPV vaccination and cervical cancer screening coverages are low. We aim to investigate the temporal and geographical trends of HPV DNA prevalence in heterosexual men, women, men who have sex with men (MSM) and people living with HIV (PLHIV) in China. Methods: We conducted a systematic review, collecting publications in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Data from January 2000 to May 2017. A total of 247 studies were selected for this meta-analysis to estimate pooled HPV prevalence, incidence of cervical cancer and risk of infection for subgroups. Meta-regression was applied to identify contributing factors to prevalence heterogeneities. Results: The national HPV prevalence was 15.6% (95% CI (14.4% to 16.9%)) in women with normal cervical cytology, and Central China had the highest prevalence (20.5% (15.2% to 25.8%)). HPV prevalence in heterosexual men (14.5% (11.3% to 17.7%)) was comparable with that of women (OR=1.09 (0.98 to 1.17)), but HPV prevalence in MSM (59.9% (52.2% to 67.6%)) was significantly higher than that in heterosexual men (OR=8.81 (8.01 to 9.69)). HIV-positive women (45.0% (38.4% to 51.6%)) and HIV-positive MSM (87.5% (82.3% to 90.9%)) had 4.67 (3.61 to 6.03) and 6.46 (5.20 to 8.02) times higher risk of HPV infection than their HIV negative counterparts. Conclusion: HPV infection is prevalent in China, particularly in Central China, in comparison with the global level and neighbouring countries. Targeted HPV vaccination for women, MSM and PLHIV and scale-up of cervical screening for women are priorities in curbing the HPV epidemic in China.

AB - Objective: Human papillomavirus (HPV) infection causes multiple cancers in both women and men. In China, both HPV vaccination and cervical cancer screening coverages are low. We aim to investigate the temporal and geographical trends of HPV DNA prevalence in heterosexual men, women, men who have sex with men (MSM) and people living with HIV (PLHIV) in China. Methods: We conducted a systematic review, collecting publications in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Data from January 2000 to May 2017. A total of 247 studies were selected for this meta-analysis to estimate pooled HPV prevalence, incidence of cervical cancer and risk of infection for subgroups. Meta-regression was applied to identify contributing factors to prevalence heterogeneities. Results: The national HPV prevalence was 15.6% (95% CI (14.4% to 16.9%)) in women with normal cervical cytology, and Central China had the highest prevalence (20.5% (15.2% to 25.8%)). HPV prevalence in heterosexual men (14.5% (11.3% to 17.7%)) was comparable with that of women (OR=1.09 (0.98 to 1.17)), but HPV prevalence in MSM (59.9% (52.2% to 67.6%)) was significantly higher than that in heterosexual men (OR=8.81 (8.01 to 9.69)). HIV-positive women (45.0% (38.4% to 51.6%)) and HIV-positive MSM (87.5% (82.3% to 90.9%)) had 4.67 (3.61 to 6.03) and 6.46 (5.20 to 8.02) times higher risk of HPV infection than their HIV negative counterparts. Conclusion: HPV infection is prevalent in China, particularly in Central China, in comparison with the global level and neighbouring countries. Targeted HPV vaccination for women, MSM and PLHIV and scale-up of cervical screening for women are priorities in curbing the HPV epidemic in China.

KW - gay men

KW - Hiv

KW - Hpv

KW - meta-analysis

KW - women

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U2 - 10.1136/sextrans-2017-053412

DO - 10.1136/sextrans-2017-053412

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JO - Sexually Transmitted Infections

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