Abstract
Aim: The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD-EPI eGFR ) and Berlin Initiative Study 1 (BIS1 eGFR ) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants. Methods: GFR was estimated using CKD-EPI and BIS1 equations. CKD was defined as eGFR <60 mL/min/1.73 m 2 or ≥ 60 mL/min/1.73 m 2 with urine albumin creatinine ratio (UACR) ≥ 3 mg/mmol. Logistic regression was used to identify predictors of CKD prevalence defined by each eGFR equation. Results: Data for analysis were complete for 17,762 participants. Mean age was 75.1 years (SD 5); 56.4% were female, 76.4% had hypertension, 9% had diabetes mellitus. Mean CKD-EPI eGFR was 73.0 (SD 14.2), compared with mean BIS1 eGFR of 62.7 (11.4). Median UACR was 0.8 (IQR 0.5, 1.5) mg/mmol. Prevalence of CKD by CKD-EPI eGFR was 27% (predominantly due to normoalbuminuric stage 3a CKD), substantially lower than 47.1% by BIS1 eGFR ; the difference was predominantly driven by reclassification of individuals from G1 and G2 CKD to stage G3a without albuminuria. Increased prevalence of CKD by either equation was related to older age, hypertension, diabetes, or higher body mass index. Conclusions: Prevalence of CKD with CKD-EPI eGFR was 27%, and doubled using the elderly specific BIS1 eGFR , with most participants reclassified from stage 2 to stage 3a. Increased prevalence of CKD was related older age, hypertension, diabetes, or increased body mass index.
| Original language | English |
|---|---|
| Number of pages | 9 |
| Journal | Nephrology |
| DOIs | |
| Publication status | Accepted/In press - 20 Jan 2019 |
Keywords
- albuminuria
- chronic kidney disease
- elderly
- estimated glomerular filtration rate
- prevalence
Cite this
}
Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort. / Polkinghorne, Kevan R.; Wolfe, Rory; Jachno, Kim M.; Wetmore, James B.; Woods, Robyn L.; McNeil, John J.; Nelson, Mark R.; Reid, Christopher M.; Murray, Anne M.; on behalf of the ASPREE Investigator Group.
In: Nephrology, 20.01.2019.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort
AU - Polkinghorne, Kevan R.
AU - Wolfe, Rory
AU - Jachno, Kim M.
AU - Wetmore, James B.
AU - Woods, Robyn L.
AU - McNeil, John J.
AU - Nelson, Mark R.
AU - Reid, Christopher M.
AU - Murray, Anne M.
AU - on behalf of the ASPREE Investigator Group
PY - 2019/1/20
Y1 - 2019/1/20
N2 - Aim: The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD-EPI eGFR ) and Berlin Initiative Study 1 (BIS1 eGFR ) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants. Methods: GFR was estimated using CKD-EPI and BIS1 equations. CKD was defined as eGFR <60 mL/min/1.73 m 2 or ≥ 60 mL/min/1.73 m 2 with urine albumin creatinine ratio (UACR) ≥ 3 mg/mmol. Logistic regression was used to identify predictors of CKD prevalence defined by each eGFR equation. Results: Data for analysis were complete for 17,762 participants. Mean age was 75.1 years (SD 5); 56.4% were female, 76.4% had hypertension, 9% had diabetes mellitus. Mean CKD-EPI eGFR was 73.0 (SD 14.2), compared with mean BIS1 eGFR of 62.7 (11.4). Median UACR was 0.8 (IQR 0.5, 1.5) mg/mmol. Prevalence of CKD by CKD-EPI eGFR was 27% (predominantly due to normoalbuminuric stage 3a CKD), substantially lower than 47.1% by BIS1 eGFR ; the difference was predominantly driven by reclassification of individuals from G1 and G2 CKD to stage G3a without albuminuria. Increased prevalence of CKD by either equation was related to older age, hypertension, diabetes, or higher body mass index. Conclusions: Prevalence of CKD with CKD-EPI eGFR was 27%, and doubled using the elderly specific BIS1 eGFR , with most participants reclassified from stage 2 to stage 3a. Increased prevalence of CKD was related older age, hypertension, diabetes, or increased body mass index.
AB - Aim: The prevalence of chronic kidney disease (CKD) in the elderly is controversial because age-related decline in kidney function may not truly reflect underlying kidney disease. We estimate the baseline prevalence and predictors of CKD using the CKD Epidemiology Collaboration (CKD-EPI eGFR ) and Berlin Initiative Study 1 (BIS1 eGFR ) eGFR equations in the ASPirin in Reducing Events in the Elderly (ASPREE) trial cohort of healthy older participants. Methods: GFR was estimated using CKD-EPI and BIS1 equations. CKD was defined as eGFR <60 mL/min/1.73 m 2 or ≥ 60 mL/min/1.73 m 2 with urine albumin creatinine ratio (UACR) ≥ 3 mg/mmol. Logistic regression was used to identify predictors of CKD prevalence defined by each eGFR equation. Results: Data for analysis were complete for 17,762 participants. Mean age was 75.1 years (SD 5); 56.4% were female, 76.4% had hypertension, 9% had diabetes mellitus. Mean CKD-EPI eGFR was 73.0 (SD 14.2), compared with mean BIS1 eGFR of 62.7 (11.4). Median UACR was 0.8 (IQR 0.5, 1.5) mg/mmol. Prevalence of CKD by CKD-EPI eGFR was 27% (predominantly due to normoalbuminuric stage 3a CKD), substantially lower than 47.1% by BIS1 eGFR ; the difference was predominantly driven by reclassification of individuals from G1 and G2 CKD to stage G3a without albuminuria. Increased prevalence of CKD by either equation was related to older age, hypertension, diabetes, or higher body mass index. Conclusions: Prevalence of CKD with CKD-EPI eGFR was 27%, and doubled using the elderly specific BIS1 eGFR , with most participants reclassified from stage 2 to stage 3a. Increased prevalence of CKD was related older age, hypertension, diabetes, or increased body mass index.
KW - albuminuria
KW - chronic kidney disease
KW - elderly
KW - estimated glomerular filtration rate
KW - prevalence
UR - http://www.scopus.com/inward/record.url?scp=85065484551&partnerID=8YFLogxK
U2 - 10.1111/nep.13565
DO - 10.1111/nep.13565
M3 - Article
JO - Nephrology
JF - Nephrology
SN - 1320-5358
ER -