TY - JOUR
T1 - Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy
AU - Fominskiy, Evgeny V.
AU - Scandroglio, Anna Mara
AU - Monti, Giacomo
AU - Calabrò, Maria Grazia
AU - Landoni, Giovanni
AU - Dell'Acqua, Antonio
AU - Beretta, Luigi
AU - Moizo, Elena
AU - Ravizza, Alfredo
AU - Monaco, Fabrizio
AU - Campochiaro, Corrado
AU - Pieri, Marina
AU - Azzolini, Maria Luisa
AU - Borghi, Giovanni
AU - Crivellari, Martina
AU - Conte, Caterina
AU - Mattioli, Cristina
AU - Silvani, Paolo
AU - Mucci, Milena
AU - Turi, Stefano
AU - Tentori, Stefano
AU - Baiardo Redaelli, Martina
AU - Sartorelli, Marianna
AU - Angelillo, Piera
AU - Belletti, Alessandro
AU - Nardelli, Pasquale
AU - Nisi, Francesco Giuseppe
AU - Valsecchi, Gabriele
AU - Barberio, Cristina
AU - Ciceri, Fabio
AU - Serpa Neto, Ary
AU - Dagna, Lorenzo
AU - Bellomo, Rinaldo
AU - Zangrillo, Alberto
AU - for the COVID-BioB Study Group
PY - 2021/1
Y1 - 2021/1
N2 - Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
AB - Background: There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems. Objective: To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients. Methods: Observational study in a tertiary care hospital in Milan, Italy. Results: Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients. Conclusions: Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
UR - http://www.scopus.com/inward/record.url?scp=85088370799&partnerID=8YFLogxK
U2 - 10.1159/000508657
DO - 10.1159/000508657
M3 - Article
C2 - 32659757
AN - SCOPUS:85088370799
VL - 50
SP - 102
EP - 109
JO - Blood Purification
JF - Blood Purification
SN - 0253-5068
IS - 1
ER -