Prevalence and Outcomes of Undiagnosed Peripheral Arterial Disease Among High Risk Patients in Australia

An Australian REACH Sub-Study

Si Si, Jonathan Golledge, Paul Norman, Mark Nelson, Derek Chew, Zanfina Ademi, Deepak L. Bhatt, Gabriel P. Steg, Christopher M. Reid

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background: Compared with other manifestations of cardiovascular disease, peripheral arterial disease (PAD) is under-diagnosed. This study aims to investigate the prevalence, risk profile and cardiovascular outcomes of undiagnosed PAD in Australian general practices. Method: A sub-study of the Australian Reduction of Atherothrombosis for Continued Health (REACH) Registry, a prospective cohort study of patients at high risk of atherothrombosis recruited from Australian general practices. Eligible patients for this study had no previous clinical diagnosis of PAD and had an ankle-brachial index (ABI) ≤1.4 at recruitment. Results: Peripheral arterial disease was undiagnosed in 34% Australian REACH participants, 28% patients had low ABI (ABI < 0.9) and 11% had intermittent claudication (IC) based on responses to the Edinburgh Claudication Questionnaire (ECQ). We found no significant differences in risk factor control between patient with or without PAD. Intermittent claudication patients had higher risks of non-fatal cardiovascular events and PAD interventions at one year, whereas all-cause mortality rate was higher among patients with ABI<0.9, especially in those who also reported IC. Finally, an ABI < 0.9, together with poorly controlled risk factors were independent predictors of incident IC at one year. Conclusions: This study suggests a high rate of undiagnosed PAD among high risk patients in Australian primary health care. These patients are at high risk of events and therefore would potentially benefit from better secondary prevention measures.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalHeart Lung and Circulation
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Ankle-brachial index
  • Australian primary health care
  • Intermittent claudication
  • Peripheral arterial disease

Cite this

Si, Si ; Golledge, Jonathan ; Norman, Paul ; Nelson, Mark ; Chew, Derek ; Ademi, Zanfina ; Bhatt, Deepak L. ; Steg, Gabriel P. ; Reid, Christopher M. / Prevalence and Outcomes of Undiagnosed Peripheral Arterial Disease Among High Risk Patients in Australia : An Australian REACH Sub-Study. In: Heart Lung and Circulation. 2019 ; Vol. 28, No. 6. pp. 939-945.
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title = "Prevalence and Outcomes of Undiagnosed Peripheral Arterial Disease Among High Risk Patients in Australia: An Australian REACH Sub-Study",
abstract = "Background: Compared with other manifestations of cardiovascular disease, peripheral arterial disease (PAD) is under-diagnosed. This study aims to investigate the prevalence, risk profile and cardiovascular outcomes of undiagnosed PAD in Australian general practices. Method: A sub-study of the Australian Reduction of Atherothrombosis for Continued Health (REACH) Registry, a prospective cohort study of patients at high risk of atherothrombosis recruited from Australian general practices. Eligible patients for this study had no previous clinical diagnosis of PAD and had an ankle-brachial index (ABI) ≤1.4 at recruitment. Results: Peripheral arterial disease was undiagnosed in 34{\%} Australian REACH participants, 28{\%} patients had low ABI (ABI < 0.9) and 11{\%} had intermittent claudication (IC) based on responses to the Edinburgh Claudication Questionnaire (ECQ). We found no significant differences in risk factor control between patient with or without PAD. Intermittent claudication patients had higher risks of non-fatal cardiovascular events and PAD interventions at one year, whereas all-cause mortality rate was higher among patients with ABI<0.9, especially in those who also reported IC. Finally, an ABI < 0.9, together with poorly controlled risk factors were independent predictors of incident IC at one year. Conclusions: This study suggests a high rate of undiagnosed PAD among high risk patients in Australian primary health care. These patients are at high risk of events and therefore would potentially benefit from better secondary prevention measures.",
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Prevalence and Outcomes of Undiagnosed Peripheral Arterial Disease Among High Risk Patients in Australia : An Australian REACH Sub-Study. / Si, Si; Golledge, Jonathan; Norman, Paul; Nelson, Mark; Chew, Derek; Ademi, Zanfina; Bhatt, Deepak L.; Steg, Gabriel P.; Reid, Christopher M.

In: Heart Lung and Circulation, Vol. 28, No. 6, 06.2019, p. 939-945.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Prevalence and Outcomes of Undiagnosed Peripheral Arterial Disease Among High Risk Patients in Australia

T2 - An Australian REACH Sub-Study

AU - Si, Si

AU - Golledge, Jonathan

AU - Norman, Paul

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AU - Chew, Derek

AU - Ademi, Zanfina

AU - Bhatt, Deepak L.

AU - Steg, Gabriel P.

AU - Reid, Christopher M.

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N2 - Background: Compared with other manifestations of cardiovascular disease, peripheral arterial disease (PAD) is under-diagnosed. This study aims to investigate the prevalence, risk profile and cardiovascular outcomes of undiagnosed PAD in Australian general practices. Method: A sub-study of the Australian Reduction of Atherothrombosis for Continued Health (REACH) Registry, a prospective cohort study of patients at high risk of atherothrombosis recruited from Australian general practices. Eligible patients for this study had no previous clinical diagnosis of PAD and had an ankle-brachial index (ABI) ≤1.4 at recruitment. Results: Peripheral arterial disease was undiagnosed in 34% Australian REACH participants, 28% patients had low ABI (ABI < 0.9) and 11% had intermittent claudication (IC) based on responses to the Edinburgh Claudication Questionnaire (ECQ). We found no significant differences in risk factor control between patient with or without PAD. Intermittent claudication patients had higher risks of non-fatal cardiovascular events and PAD interventions at one year, whereas all-cause mortality rate was higher among patients with ABI<0.9, especially in those who also reported IC. Finally, an ABI < 0.9, together with poorly controlled risk factors were independent predictors of incident IC at one year. Conclusions: This study suggests a high rate of undiagnosed PAD among high risk patients in Australian primary health care. These patients are at high risk of events and therefore would potentially benefit from better secondary prevention measures.

AB - Background: Compared with other manifestations of cardiovascular disease, peripheral arterial disease (PAD) is under-diagnosed. This study aims to investigate the prevalence, risk profile and cardiovascular outcomes of undiagnosed PAD in Australian general practices. Method: A sub-study of the Australian Reduction of Atherothrombosis for Continued Health (REACH) Registry, a prospective cohort study of patients at high risk of atherothrombosis recruited from Australian general practices. Eligible patients for this study had no previous clinical diagnosis of PAD and had an ankle-brachial index (ABI) ≤1.4 at recruitment. Results: Peripheral arterial disease was undiagnosed in 34% Australian REACH participants, 28% patients had low ABI (ABI < 0.9) and 11% had intermittent claudication (IC) based on responses to the Edinburgh Claudication Questionnaire (ECQ). We found no significant differences in risk factor control between patient with or without PAD. Intermittent claudication patients had higher risks of non-fatal cardiovascular events and PAD interventions at one year, whereas all-cause mortality rate was higher among patients with ABI<0.9, especially in those who also reported IC. Finally, an ABI < 0.9, together with poorly controlled risk factors were independent predictors of incident IC at one year. Conclusions: This study suggests a high rate of undiagnosed PAD among high risk patients in Australian primary health care. These patients are at high risk of events and therefore would potentially benefit from better secondary prevention measures.

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JO - Heart Lung and Circulation

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