Pretreatment neutrophil-to-lymphocyte/monocyte-to-lymphocyte ratio as prognostic biomarkers in glioma patients

Sher Ting Chim, Paul Sanfilippo, Terence J. O'Brien, Kate J. Drummond, Mastura Monif

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9 Citations (Scopus)

Abstract

Objectives: To evaluate the ability for pre-treatment NLR and MLR to predict overall survival (OS) and modified Rankin Scale (mRS) and to explore their relationship with clinicopathological parameters. Methods: Retrospective analysis of pretreatment NLR and MLR from 64 glioma patients. Results: Higher pretreatment NLR (>4.7) predicted higher mean admission mRS (p < 0.001) and 6-month mRS (p = 0.02). Higher pretreatment MLR (>0.35) was a risk factor for poorer OS in glioma patients (p = 0.024). Higher pretreatment NLR was significantly associated with larger tumor diameter (p = 0.02). Conclusion: NLR and MLR can serve as prognostic markers to predict functional outcomes and OS in glioma patients

Original languageEnglish
Article number577754
Number of pages11
JournalJournal of Neuroimmunology
Volume361
DOIs
Publication statusPublished - 15 Dec 2021

Keywords

  • glioma
  • MLR
  • NLR
  • prognosis

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