Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Sun Loo; Nicola Potter; Adam Ivey; Jenny O'Nions; Roderick Moon; Jelena Jovanovic; Chun Y. Fong; Natasha S. Anstee; Ing Soo Tiong; Jad Othman; Chong Chyn Chua; Hanna Renshaw; Robert Baker; Shaun Fleming; Nigel H. Russell; David Ritchie; Ashish Bajel; Hsin An Hou; Richard Dillon; Andrew H. Wei

doi:10.1182/blood.2024026605

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Sun Loo
, Nicola Potter
, Adam Ivey
, Jenny O'Nions
, Roderick Moon
, Jelena Jovanovic
, Chun Y. Fong
, Natasha S. Anstee
, Ing Soo Tiong
, Jad Othman
, Chong Chyn Chua
, Hanna Renshaw
, Robert Baker
, Shaun Fleming
, Nigel H. Russell
, David Ritchie
, Ashish Bajel
, Hsin An Hou
, Richard Dillon
, Andrew H. Wei

Australian Centre for Blood Diseases

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).

Original language	English
Pages (from-to)	2554-2557
Number of pages	4
Journal	Blood
Volume	144
Issue number	24
DOIs	https://doi.org/10.1182/blood.2024026605
Publication status	Published - 12 Dec 2024

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10.1182/blood.2024026605

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Loo, S., Potter, N., Ivey, A., O'Nions, J., Moon, R., Jovanovic, J., Fong, C. Y., Anstee, N. S., Tiong, I. S., Othman, J., Chua, C. C., Renshaw, H., Baker, R., Fleming, S., Russell, N. H., Ritchie, D., Bajel, A., Hou, H. A., Dillon, R., & Wei, A. H. (2024). Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia. Blood, 144(24), 2554-2557. https://doi.org/10.1182/blood.2024026605

@article{687900ae0d7448eea57738ea7ba544bc,

title = "Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia",

abstract = "Pretransplant detection of KMT2Ar measurable residual disease ≥0.001\% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17\% vs 59\%; P = .001) and increased 2-year cumulative incidence of relapse (75\% vs 25\%, P = .0004).",

author = "Sun Loo and Nicola Potter and Adam Ivey and Jenny O'Nions and Roderick Moon and Jelena Jovanovic and Fong, \{Chun Y.\} and Anstee, \{Natasha S.\} and Tiong, \{Ing Soo\} and Jad Othman and Chua, \{Chong Chyn\} and Hanna Renshaw and Robert Baker and Shaun Fleming and Russell, \{Nigel H.\} and David Ritchie and Ashish Bajel and Hou, \{Hsin An\} and Richard Dillon and Wei, \{Andrew H.\}",

note = "Publisher Copyright: {\textcopyright} 2024 American Society of Hematology",

year = "2024",

month = dec,

day = "12",

doi = "10.1182/blood.2024026605",

language = "English",

volume = "144",

pages = "2554--2557",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "24",

}

Loo, S, Potter, N, Ivey, A, O'Nions, J, Moon, R, Jovanovic, J, Fong, CY, Anstee, NS, Tiong, IS, Othman, J, Chua, CC, Renshaw, H, Baker, R, Fleming, S, Russell, NH, Ritchie, D, Bajel, A, Hou, HA, Dillon, R & Wei, AH 2024, 'Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia', Blood, vol. 144, no. 24, pp. 2554-2557. https://doi.org/10.1182/blood.2024026605

TY - JOUR

T1 - Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

AU - Loo, Sun

AU - Potter, Nicola

AU - Ivey, Adam

AU - O'Nions, Jenny

AU - Moon, Roderick

AU - Jovanovic, Jelena

AU - Fong, Chun Y.

AU - Anstee, Natasha S.

AU - Tiong, Ing Soo

AU - Othman, Jad

AU - Chua, Chong Chyn

AU - Renshaw, Hanna

AU - Baker, Robert

AU - Fleming, Shaun

AU - Russell, Nigel H.

AU - Ritchie, David

AU - Bajel, Ashish

AU - Hou, Hsin An

AU - Dillon, Richard

AU - Wei, Andrew H.

PY - 2024/12/12

Y1 - 2024/12/12

N2 - Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).

AB - Pretransplant detection of KMT2Ar measurable residual disease ≥0.001% by quantitative polymerase chain reaction was associated with significantly inferior posttransplant survival (2-year relapse-free survival 17% vs 59%; P = .001) and increased 2-year cumulative incidence of relapse (75% vs 25%, P = .0004).

UR - https://www.scopus.com/pages/publications/85208242466

U2 - 10.1182/blood.2024026605

DO - 10.1182/blood.2024026605

M3 - Article

C2 - 39316646

AN - SCOPUS:85208242466

SN - 0006-4971

VL - 144

SP - 2554

EP - 2557

JO - Blood

JF - Blood

IS - 24

ER -

Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Abstract

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Transforming the treatment landscape in elderly Acute Myeloid Leukaemia (AML)

Translational Research Program to Advance Clinical Outcomes in Acute Myeloid Leukaemia

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Pretransplant MRD detection of fusion transcripts is strongly prognostic in KMT2A-rearranged acute myeloid leukemia

Abstract

Access to Document

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Projects

Transforming the treatment landscape in elderly Acute Myeloid Leukaemia (AML)

Translational Research Program to Advance Clinical Outcomes in Acute Myeloid Leukaemia

Cite this