Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 337 - 342 |
| Number of pages | 6 |
| Journal | Acta Paediatrica |
| Volume | 103 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
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Preterm lambs given intravenous dopamine show increased dopamine in their cerebrospinal fluid. / Olhager, Elisabeth; Nold, Claudia Annelie; Joshi, Mandar; Doery, James C G; Samarasinghe, Thilini Damsarani; Walker, Adrian Mark; Wong, Flora Yuen-Wait.
In: Acta Paediatrica, Vol. 103, No. 3, 2014, p. 337 - 342.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Preterm lambs given intravenous dopamine show increased dopamine in their cerebrospinal fluid
AU - Olhager, Elisabeth
AU - Nold, Claudia Annelie
AU - Joshi, Mandar
AU - Doery, James C G
AU - Samarasinghe, Thilini Damsarani
AU - Walker, Adrian Mark
AU - Wong, Flora Yuen-Wait
PY - 2014
Y1 - 2014
N2 - Dopamine is used as an inotropic medication in preterm infants. The preterm human blood brain barrier (BBB) is permeable to intravascular dopamine, and the impact of exogenous dopamine on the preterm brain remains unknown. The preterm lamb model may be suitable for studying the cerebral impact of dopamine therapy whether its BBB permeability is similar to preterm human infants. We aimed to examine BBB permeability to exogenous dopamine in the preterm lamb, by measuring dopamine levels in the cerebrospinal fluid (CSF). METHODS: Nine preterm foetal lambs (125-130 days, term = 147 days) were given either dopamine at 10 mug/kg/min (dopamine, n = 4) or saline (control, n = 5). CSF, and plasma samples were taken for dopamine assay. RESULTS: The median (range) baseline CSF dopamine level for the combined control and dopamine groups (n = 9) was 0.10(0.03-0.16) ng/mL, and baseline plasma dopamine was 0.30(0.13-0.84) ng/mL. The dopamine lambs showed increase in CSF dopamine to 3.91(1.87-11.35) ng/mL with plasma dopamine increased to 14.2 (9.1-57.9) ng/mL. No change was found in the control lambs. CONCLUSION: In the preterm lamb, the BBB permeability and pharmacokinetics to dopamine infusion are similar to findings in the preterm human infant, supporting applicability of the preterm lamb model for studying effects of dopamine infusion in the preterm human brain.
AB - Dopamine is used as an inotropic medication in preterm infants. The preterm human blood brain barrier (BBB) is permeable to intravascular dopamine, and the impact of exogenous dopamine on the preterm brain remains unknown. The preterm lamb model may be suitable for studying the cerebral impact of dopamine therapy whether its BBB permeability is similar to preterm human infants. We aimed to examine BBB permeability to exogenous dopamine in the preterm lamb, by measuring dopamine levels in the cerebrospinal fluid (CSF). METHODS: Nine preterm foetal lambs (125-130 days, term = 147 days) were given either dopamine at 10 mug/kg/min (dopamine, n = 4) or saline (control, n = 5). CSF, and plasma samples were taken for dopamine assay. RESULTS: The median (range) baseline CSF dopamine level for the combined control and dopamine groups (n = 9) was 0.10(0.03-0.16) ng/mL, and baseline plasma dopamine was 0.30(0.13-0.84) ng/mL. The dopamine lambs showed increase in CSF dopamine to 3.91(1.87-11.35) ng/mL with plasma dopamine increased to 14.2 (9.1-57.9) ng/mL. No change was found in the control lambs. CONCLUSION: In the preterm lamb, the BBB permeability and pharmacokinetics to dopamine infusion are similar to findings in the preterm human infant, supporting applicability of the preterm lamb model for studying effects of dopamine infusion in the preterm human brain.
UR - http://onlinelibrary.wiley.com/doi/10.1111/apa.12520/epdf
U2 - 10.1111/apa.12520
DO - 10.1111/apa.12520
M3 - Article
VL - 103
SP - 337
EP - 342
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 3
ER -