Preterm hypoxic-ischemic encephalopathy

Krishna Revanna Gopagondanahalli, Jingang Li, Michael C. Fahey, Rod W. Hunt, Graham Jenkin, Suzanne L. Miller, Atul Malhotra

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

Hypoxic-ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic-ischemic episode before or during birth. However, in the preterm infant, defining hypoxic-ischemic injury (HII), its clinical course, monitoring, and outcomes remains complex. Few studies examine preterm HIE, and these are heterogeneous, with variable inclusion criteria and outcomes reported. We examine the available evidence that implies that the incidence of hypoxic-ischemic insult in preterm infants is probably higher than recognized and follows a more complex clinical course, with higher rates of adverse neurological outcomes, compared to term infants. This review aims to elucidate the causes and consequences of preterm hypoxia-ischemia, the subsequent clinical encephalopathy syndrome, diagnostic tools, and outcomes. Finally, we suggest a uniform definition for preterm HIE that may help in identifying infants most at risk of adverse outcomes and amenable to neuroprotective therapies.

Original languageEnglish
Article number114
Number of pages10
JournalFrontiers in Pediatrics
Volume4
Issue numberOCT
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Asphyxia
  • Cerebral palsy
  • Encephalopathy
  • Excitotoxicity
  • Preterm brain injury

Cite this

Gopagondanahalli, Krishna Revanna ; Li, Jingang ; Fahey, Michael C. ; Hunt, Rod W. ; Jenkin, Graham ; Miller, Suzanne L. ; Malhotra, Atul. / Preterm hypoxic-ischemic encephalopathy. In: Frontiers in Pediatrics. 2016 ; Vol. 4, No. OCT.
@article{56fe8191833a459e83793b048d05805e,
title = "Preterm hypoxic-ischemic encephalopathy",
abstract = "Hypoxic-ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic-ischemic episode before or during birth. However, in the preterm infant, defining hypoxic-ischemic injury (HII), its clinical course, monitoring, and outcomes remains complex. Few studies examine preterm HIE, and these are heterogeneous, with variable inclusion criteria and outcomes reported. We examine the available evidence that implies that the incidence of hypoxic-ischemic insult in preterm infants is probably higher than recognized and follows a more complex clinical course, with higher rates of adverse neurological outcomes, compared to term infants. This review aims to elucidate the causes and consequences of preterm hypoxia-ischemia, the subsequent clinical encephalopathy syndrome, diagnostic tools, and outcomes. Finally, we suggest a uniform definition for preterm HIE that may help in identifying infants most at risk of adverse outcomes and amenable to neuroprotective therapies.",
keywords = "Asphyxia, Cerebral palsy, Encephalopathy, Excitotoxicity, Preterm brain injury",
author = "Gopagondanahalli, {Krishna Revanna} and Jingang Li and Fahey, {Michael C.} and Hunt, {Rod W.} and Graham Jenkin and Miller, {Suzanne L.} and Atul Malhotra",
year = "2016",
month = "10",
day = "1",
doi = "10.3389/fped.2016.00114",
language = "English",
volume = "4",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media",
number = "OCT",

}

Preterm hypoxic-ischemic encephalopathy. / Gopagondanahalli, Krishna Revanna; Li, Jingang; Fahey, Michael C.; Hunt, Rod W.; Jenkin, Graham; Miller, Suzanne L.; Malhotra, Atul.

In: Frontiers in Pediatrics, Vol. 4, No. OCT, 114, 01.10.2016.

Research output: Contribution to journalReview ArticleOtherpeer-review

TY - JOUR

T1 - Preterm hypoxic-ischemic encephalopathy

AU - Gopagondanahalli, Krishna Revanna

AU - Li, Jingang

AU - Fahey, Michael C.

AU - Hunt, Rod W.

AU - Jenkin, Graham

AU - Miller, Suzanne L.

AU - Malhotra, Atul

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Hypoxic-ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic-ischemic episode before or during birth. However, in the preterm infant, defining hypoxic-ischemic injury (HII), its clinical course, monitoring, and outcomes remains complex. Few studies examine preterm HIE, and these are heterogeneous, with variable inclusion criteria and outcomes reported. We examine the available evidence that implies that the incidence of hypoxic-ischemic insult in preterm infants is probably higher than recognized and follows a more complex clinical course, with higher rates of adverse neurological outcomes, compared to term infants. This review aims to elucidate the causes and consequences of preterm hypoxia-ischemia, the subsequent clinical encephalopathy syndrome, diagnostic tools, and outcomes. Finally, we suggest a uniform definition for preterm HIE that may help in identifying infants most at risk of adverse outcomes and amenable to neuroprotective therapies.

AB - Hypoxic-ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic-ischemic episode before or during birth. However, in the preterm infant, defining hypoxic-ischemic injury (HII), its clinical course, monitoring, and outcomes remains complex. Few studies examine preterm HIE, and these are heterogeneous, with variable inclusion criteria and outcomes reported. We examine the available evidence that implies that the incidence of hypoxic-ischemic insult in preterm infants is probably higher than recognized and follows a more complex clinical course, with higher rates of adverse neurological outcomes, compared to term infants. This review aims to elucidate the causes and consequences of preterm hypoxia-ischemia, the subsequent clinical encephalopathy syndrome, diagnostic tools, and outcomes. Finally, we suggest a uniform definition for preterm HIE that may help in identifying infants most at risk of adverse outcomes and amenable to neuroprotective therapies.

KW - Asphyxia

KW - Cerebral palsy

KW - Encephalopathy

KW - Excitotoxicity

KW - Preterm brain injury

UR - http://www.scopus.com/inward/record.url?scp=85057421663&partnerID=8YFLogxK

U2 - 10.3389/fped.2016.00114

DO - 10.3389/fped.2016.00114

M3 - Review Article

VL - 4

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

SN - 2296-2360

IS - OCT

M1 - 114

ER -