Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants

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24 Citations (Scopus)

Abstract

OBJECTIVE: Impaired blood pressure (BP) control may underpin the increased incidence of the sudden infant death syndrome (SIDS) in preterm infants. This study aimed to examine the effects of preterm birth, postnatal age, and sleep state on BP control by measuring baroreflex sensitivity (BRS) across the first 6 months of term-corrected age (CA), when SIDS risk is greatest. METHODS: Preterm (n = 25) and term (n = 31) infants were studied longitudinally at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months CA using daytime polysomnography. BP was recorded during quiet (QS) and active (AS) sleep using a photoplethysmographic cuff placed around the infant s wrist (Finometer [FMS, Finapres Medical Systems, Amsterdam, Netherlands]). BRS (milliseconds/mm Hg) was assessed in 1- to 2-minute epochs using cross-spectral analysis. RESULTS: In preterm infants, postnatal age had no significant effect on BRS within either QS or AS. This was in contrast to the maturational increase in QS observed in term infants. Compared with term infants, BRS of preterm infants was 38 higher at 2 to 4 weeks CA and 29 lower at 5 to 6 months CA during QS (P
Original languageEnglish
Pages (from-to)89 - 96
Number of pages8
JournalPediatrics
Volume129
Issue number1
DOIs
Publication statusPublished - 2012

Cite this

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title = "Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants",
abstract = "OBJECTIVE: Impaired blood pressure (BP) control may underpin the increased incidence of the sudden infant death syndrome (SIDS) in preterm infants. This study aimed to examine the effects of preterm birth, postnatal age, and sleep state on BP control by measuring baroreflex sensitivity (BRS) across the first 6 months of term-corrected age (CA), when SIDS risk is greatest. METHODS: Preterm (n = 25) and term (n = 31) infants were studied longitudinally at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months CA using daytime polysomnography. BP was recorded during quiet (QS) and active (AS) sleep using a photoplethysmographic cuff placed around the infant s wrist (Finometer [FMS, Finapres Medical Systems, Amsterdam, Netherlands]). BRS (milliseconds/mm Hg) was assessed in 1- to 2-minute epochs using cross-spectral analysis. RESULTS: In preterm infants, postnatal age had no significant effect on BRS within either QS or AS. This was in contrast to the maturational increase in QS observed in term infants. Compared with term infants, BRS of preterm infants was 38 higher at 2 to 4 weeks CA and 29 lower at 5 to 6 months CA during QS (P",
author = "Nicole Witcombe and Stephanie Yiallourou and Scott Sands and Adrian Walker and Horne, {Rosemary Sylvia Claire}",
year = "2012",
doi = "10.1542/peds.2011-1504",
language = "English",
volume = "129",
pages = "89 -- 96",
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Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants. / Witcombe, Nicole; Yiallourou, Stephanie; Sands, Scott; Walker, Adrian; Horne, Rosemary Sylvia Claire.

In: Pediatrics, Vol. 129, No. 1, 2012, p. 89 - 96.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Preterm birth alters the maturation of baroreflex sensitivity in sleeping infants

AU - Witcombe, Nicole

AU - Yiallourou, Stephanie

AU - Sands, Scott

AU - Walker, Adrian

AU - Horne, Rosemary Sylvia Claire

PY - 2012

Y1 - 2012

N2 - OBJECTIVE: Impaired blood pressure (BP) control may underpin the increased incidence of the sudden infant death syndrome (SIDS) in preterm infants. This study aimed to examine the effects of preterm birth, postnatal age, and sleep state on BP control by measuring baroreflex sensitivity (BRS) across the first 6 months of term-corrected age (CA), when SIDS risk is greatest. METHODS: Preterm (n = 25) and term (n = 31) infants were studied longitudinally at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months CA using daytime polysomnography. BP was recorded during quiet (QS) and active (AS) sleep using a photoplethysmographic cuff placed around the infant s wrist (Finometer [FMS, Finapres Medical Systems, Amsterdam, Netherlands]). BRS (milliseconds/mm Hg) was assessed in 1- to 2-minute epochs using cross-spectral analysis. RESULTS: In preterm infants, postnatal age had no significant effect on BRS within either QS or AS. This was in contrast to the maturational increase in QS observed in term infants. Compared with term infants, BRS of preterm infants was 38 higher at 2 to 4 weeks CA and 29 lower at 5 to 6 months CA during QS (P

AB - OBJECTIVE: Impaired blood pressure (BP) control may underpin the increased incidence of the sudden infant death syndrome (SIDS) in preterm infants. This study aimed to examine the effects of preterm birth, postnatal age, and sleep state on BP control by measuring baroreflex sensitivity (BRS) across the first 6 months of term-corrected age (CA), when SIDS risk is greatest. METHODS: Preterm (n = 25) and term (n = 31) infants were studied longitudinally at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months CA using daytime polysomnography. BP was recorded during quiet (QS) and active (AS) sleep using a photoplethysmographic cuff placed around the infant s wrist (Finometer [FMS, Finapres Medical Systems, Amsterdam, Netherlands]). BRS (milliseconds/mm Hg) was assessed in 1- to 2-minute epochs using cross-spectral analysis. RESULTS: In preterm infants, postnatal age had no significant effect on BRS within either QS or AS. This was in contrast to the maturational increase in QS observed in term infants. Compared with term infants, BRS of preterm infants was 38 higher at 2 to 4 weeks CA and 29 lower at 5 to 6 months CA during QS (P

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U2 - 10.1542/peds.2011-1504

DO - 10.1542/peds.2011-1504

M3 - Article

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EP - 96

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