Abstract
Background: Renal function is an important prescribing consideration. On average, glomerular filtration rate declines by about 10 mL/min every 10 years after the age of 40. Renal impairment may cause medicines to accumulate or cause toxicity, especially if the medicine has a narrow therapeutic index.
Objective: To present an overview of prescribing considerations in the primary care setting for patients with chronic renal impairment.
Discussion: Serum creatinine considered in isolation is not a reliable indicator of renal function. The estimated glomerular filtration rate provided in pathology reporting can alert prescribers to possible renal impairment and the need to consider dose adjustments. The Cockcroft-Gault equation should be used to adjust medicine doses. Renal function monitoring is recommended for patients using medicines that can impair renal function or cause nephrotoxicity (eg. NSAIDs, ACEIs, ARBs).
| Original language | English |
|---|---|
| Pages (from-to) | 24-28 |
| Number of pages | 5 |
| Journal | Australian Family Physician |
| Volume | 42 |
| Issue number | 1 |
| Publication status | Published - Jan 2013 |
| Externally published | Yes |
Keywords
- Aged
- Pharmaceutical preparations/ administration and dosage
- Renal insufficiency