Preparation of in situ-forming poly(5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one)-poly(ethylene glycol) hydrogels with tuneable swelling, mechanical strength and degradability

Vinh Xuan Truong, Ian A Barker, Milene Tan, Laetitia Mespouille, Philippe Dubois, Andrew P Dove

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

This work describes the preparation of a new class of in situ-forming poly(carbonate)-graft-poly(ethylene glycol) hybrid hydrogels using thiol-ene photoclick chemistry. Morphological study by cryogenic Scanning Electron Microscopy (SEM) revealed that the hydrogels display characteristic macroporous and microporous distributions, the ratio of which can be tuned by varying the length of the poly(ethylene glycol) linker. Controlling the side-chain length of the poly(ethylene glycol) also allows tuning of the equilibrium water uptake, water diffusion, mechanical properties and degradability. Furthermore, we demonstrate that these hydrogels are robust materials with fracture compressive strength in the range of 27-468 kPa and are readily degraded under physiological conditions between 8 and 22 days. The swelling of the gels was also found to be thermoresponsive making them potential candidates for delivery applications
Original languageEnglish
Pages (from-to)221 - 229
Number of pages9
JournalJournal of Materials Chemistry B
Volume1
Issue number2
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this

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title = "Preparation of in situ-forming poly(5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one)-poly(ethylene glycol) hydrogels with tuneable swelling, mechanical strength and degradability",
abstract = "This work describes the preparation of a new class of in situ-forming poly(carbonate)-graft-poly(ethylene glycol) hybrid hydrogels using thiol-ene photoclick chemistry. Morphological study by cryogenic Scanning Electron Microscopy (SEM) revealed that the hydrogels display characteristic macroporous and microporous distributions, the ratio of which can be tuned by varying the length of the poly(ethylene glycol) linker. Controlling the side-chain length of the poly(ethylene glycol) also allows tuning of the equilibrium water uptake, water diffusion, mechanical properties and degradability. Furthermore, we demonstrate that these hydrogels are robust materials with fracture compressive strength in the range of 27-468 kPa and are readily degraded under physiological conditions between 8 and 22 days. The swelling of the gels was also found to be thermoresponsive making them potential candidates for delivery applications",
author = "Truong, {Vinh Xuan} and Barker, {Ian A} and Milene Tan and Laetitia Mespouille and Philippe Dubois and Dove, {Andrew P}",
year = "2013",
doi = "10.1039/c2tb00148a",
language = "English",
volume = "1",
pages = "221 -- 229",
journal = "Journal of Materials Chemistry B",
issn = "2050-750X",
publisher = "The Royal Society of Chemistry",
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}

Preparation of in situ-forming poly(5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one)-poly(ethylene glycol) hydrogels with tuneable swelling, mechanical strength and degradability. / Truong, Vinh Xuan; Barker, Ian A; Tan, Milene; Mespouille, Laetitia; Dubois, Philippe; Dove, Andrew P.

In: Journal of Materials Chemistry B, Vol. 1, No. 2, 2013, p. 221 - 229.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Preparation of in situ-forming poly(5-methyl-5-allyloxycarbonyl-1,3-dioxan-2-one)-poly(ethylene glycol) hydrogels with tuneable swelling, mechanical strength and degradability

AU - Truong, Vinh Xuan

AU - Barker, Ian A

AU - Tan, Milene

AU - Mespouille, Laetitia

AU - Dubois, Philippe

AU - Dove, Andrew P

PY - 2013

Y1 - 2013

N2 - This work describes the preparation of a new class of in situ-forming poly(carbonate)-graft-poly(ethylene glycol) hybrid hydrogels using thiol-ene photoclick chemistry. Morphological study by cryogenic Scanning Electron Microscopy (SEM) revealed that the hydrogels display characteristic macroporous and microporous distributions, the ratio of which can be tuned by varying the length of the poly(ethylene glycol) linker. Controlling the side-chain length of the poly(ethylene glycol) also allows tuning of the equilibrium water uptake, water diffusion, mechanical properties and degradability. Furthermore, we demonstrate that these hydrogels are robust materials with fracture compressive strength in the range of 27-468 kPa and are readily degraded under physiological conditions between 8 and 22 days. The swelling of the gels was also found to be thermoresponsive making them potential candidates for delivery applications

AB - This work describes the preparation of a new class of in situ-forming poly(carbonate)-graft-poly(ethylene glycol) hybrid hydrogels using thiol-ene photoclick chemistry. Morphological study by cryogenic Scanning Electron Microscopy (SEM) revealed that the hydrogels display characteristic macroporous and microporous distributions, the ratio of which can be tuned by varying the length of the poly(ethylene glycol) linker. Controlling the side-chain length of the poly(ethylene glycol) also allows tuning of the equilibrium water uptake, water diffusion, mechanical properties and degradability. Furthermore, we demonstrate that these hydrogels are robust materials with fracture compressive strength in the range of 27-468 kPa and are readily degraded under physiological conditions between 8 and 22 days. The swelling of the gels was also found to be thermoresponsive making them potential candidates for delivery applications

U2 - 10.1039/c2tb00148a

DO - 10.1039/c2tb00148a

M3 - Article

VL - 1

SP - 221

EP - 229

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-750X

IS - 2

ER -