Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei Wei, Guang-Hui Ma, Gang Hu, Di Yu, Tom McLeish, Zhi-Guo Su, Zhe-Yun Shen

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427 Citations (Scopus)


One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
Original languageEnglish
Pages (from-to)15808 - 15810
Number of pages3
JournalJournal of the American Chemical Society
Issue number47
Publication statusPublished - 2008
Externally publishedYes

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