Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei Wei; Guang-Hui Ma; Gang Hu; Di Yu; Tom McLeish; Zhi-Guo Su; Zhe-Yun Shen

doi:10.1021/ja8039585

Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Wei Wei, Guang-Hui Ma, Gang Hu, Di Yu, Tom McLeish, Zhi-Guo Su, Zhe-Yun Shen

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

Original language	English
Pages (from-to)	15808 - 15810
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	130
Issue number	47
DOIs	https://doi.org/10.1021/ja8039585
Publication status	Published - 2008
Externally published	Yes

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10.1021/ja8039585

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abstract = "One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.",

author = "Wei Wei and Guang-Hui Ma and Gang Hu and Di Yu and Tom McLeish and Zhi-Guo Su and Zhe-Yun Shen",

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AU - McLeish, Tom

AU - Su, Zhi-Guo

AU - Shen, Zhe-Yun

PY - 2008

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AB - One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.

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Preparation of hierarchical hollow CaCO3 particles and the application as anticancer drug carrier

Abstract

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