Preparation of cyclic peptide libraries using intramolecular oxime formation

Kade D. Roberts; John N. Lambert; Nicholas J. Ede; Andrew M. Bray

doi:10.1002/psc.575

Preparation of cyclic peptide libraries using intramolecular oxime formation

Kade D. Roberts, John N. Lambert, Nicholas J. Ede, Andrew M. Bray

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.

Original language	English
Pages (from-to)	659-665
Number of pages	7
Journal	Journal of Peptide Science
Volume	10
Issue number	11
DOIs	https://doi.org/10.1002/psc.575
Publication status	Published - 1 Nov 2004
Externally published	Yes

Keywords

Cyclic peptides
Oxime formation
Peptide libraries
Solid phase peptide synthesis

Access to Document

10.1002/psc.575

Link to publication in Scopus

Cite this

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abstract = "A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.",

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AU - Lambert, John N.

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AU - Bray, Andrew M.

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KW - Peptide libraries

KW - Solid phase peptide synthesis

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