Preparation of cyclic peptide libraries using intramolecular oxime formation

Kade D. Roberts, John N. Lambert, Nicholas J. Ede, Andrew M. Bray

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14 Citations (Scopus)

Abstract

A new method for the synthesis of cyclic head-to-side chain peptide libraries has been developed in which the key cyclization step involves reaction between a C-terminal ketone and an N-terminal hydroxylamine to form a macrocyclic oxime. This methodology efficiently delivers cyclic products that consist of mixtures of syn and anti isomers.

Original languageEnglish
Pages (from-to)659-665
Number of pages7
JournalJournal of Peptide Science
Volume10
Issue number11
DOIs
Publication statusPublished - 1 Nov 2004
Externally publishedYes

Keywords

  • Cyclic peptides
  • Oxime formation
  • Peptide libraries
  • Solid phase peptide synthesis

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