Preparation of chiral graphene oxides by covalent attachment of chiral cysteines for voltammetric recognition of tartrates

Hui Huang, Lulu Hu, Yue Sun, Yang Liu, Zhenhui Kang, Douglas R. MacFarlane

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The authors describe the preparation of a chiral graphene oxides (GOs) by covalent attachment of D- or L-cysteine using a one-step hydrothermal method. The resulting chiral functionalized GOs shows circular dichroism with intensities similar to those produced by the cysteines. This indicates that the chirality of cysteines is well preserved in the chiral GOs. The material is reasonably stable at temperatures from 20 to 200 °C and at pH values from 0 to 14. A glassy carbon electrode (GCE) was modified with the chiral GOs and then tested for recognition capability for L- and D-tartrate (0.5 mM). The enantioselectivity of the chiral GOs appears to be the result of a synergistic effect where GO increases the conductivity and cysteine provides the chiral environment. The method is assumed to provide a useful general scheme for development of advanced carbonaceous materials with chiral recognition capabilities. 

Original languageEnglish
Article number298
Number of pages9
JournalMicrochimica Acta
Volume186
Issue number5
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • Chiral amino acids
  • Chiral graphene oxide
  • Chirality
  • Covalent attachment
  • Enantioselectivity recognition
  • Stability

Cite this