Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose

Fanny Joubert, R. Paul Yeo, Gary J. Sharples, Osama M. Musa, David R. W. Hodgson, Neil R. Cameron

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16 Citations (Scopus)

Abstract

Poly(ionic liquid)s (P(IL)s) of different degrees of polymerization (10, 50, and 100) were prepared via RAFT polymerization using an alkyne-terminated xanthate as transfer agent, with a monomer conversion of up to ∼80% and a ĐM of 1.5 for P(IL)100. Subsequently, P(IL) chains were coupled to 15N-labeled azido-functionalized hydroxyethyl cellulose (HEC), forming graft copolymers of HEC with different chain length and graft densities, which were characterized using (13C and 15N) CP-MAS NMR and FT-IR spectroscopies. The antibacterial activities of HEC-g-P(IL)s were tested against Escherichia coli and Staphylococcus aureus and were comparable to ampicillin, a well-known antibiotic, demonstrating efficient activity of the graft copolymers against bacteria. Moreover, HEC-g-P(IL)s were slightly more effective against E. coli than S. aureus. A decrease in graft density of P(IL)10 on the HEC backbone decreased the activity of the graft copolymers against both bacteria. These findings suggest that HEC-g-P(IL) could find applications as an antiseptic compound, for example, in paint formulation.
Original languageEnglish
Pages (from-to)3970 - 3979
Number of pages10
JournalBiomacromolecules
Volume16
Issue number12
DOIs
Publication statusPublished - 2015

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