Preparation and characterization of intravenously injectable nimodipine nanosuspension

Ruolan Xiong, Weigen Lu, Jun Li, Peiquan Wang, Rong Xu, Tingting Chen

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90 Citations (Scopus)

Abstract

The purpose of this study was to develop an alternative, improved and better tolerated injectable nimodipine nanosuspension compared with commercially available ethanol solution. In this study, nimodipine nanosuspension was prepared by high-pressure homogenization (HPH). The effects of the production parameters such as pressure, cycle numbers and crushing principles on the mean particle size, 99% diameter and polydispersity of the nanosuspension were investigated. Characterization of the product was performed by scanning electron microscope (SEM) and differential scanning calorimeter (DSC). The safety of the nimodipine nanosuspension was discussed with special attention to contamination by microparticles and the increase in saturation solubility Cs. Irritability study in rabbits showed that this formulation provided less local irritation and phlebitis risks than the commercial ethanol product, which represented a promising new drug formulation for intravenous therapy of subarachnoid hemorrhage (SAH)-related vasospasm.

Original languageEnglish
Pages (from-to)338-343
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume350
Issue number1-2
DOIs
Publication statusPublished - 28 Feb 2008
Externally publishedYes

Keywords

  • Crystal form
  • High-pressure homogenization
  • Nanosuspension
  • Nimodipine
  • Vascular irritation

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