Preoperative urinary neutrophil gelatinase-associated lipocalin and outcome in high-risk heart failure patients undergoing cardiac surgery

Simona Silvetti, Roberta Meroni, Elena Bignami, Tiziana Bove, Giovanni Landoni, Alberto Zangrillo, Rinaldo Bellomo, Federico Pappalardo

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Objective To investigate the ability of early urinary neutrophil gelatinase-associated lipocalin to predict postoperative complications in adult patients with ventricular dysfunction undergoing cardiac surgery. Design Prospective observational study. Setting Single-center study, university hospital. Participants Fifty-six adult high-risk cardiac surgical patients with preoperative cardiac failure. Interventions None. Measurements and Main Results Demographic and clinical characteristics were obtained, and neutrophil gelatinase-associated lipocalin was measured at baseline and at several time points after surgery. Patient characteristics and neutrophil gelatinase-associated lipocalin levels were related to renal and patient outcome. On multivariate analyses, preoperative urinary neutrophil gelatinase-associated lipocalin was an independent predictor of length of intensive care stay (p = 0.004) and in-hospital stay (p = 0.04), but not of acute kidney injury or renal replacement therapy and was not associated with baseline renal function. Conclusions In a cohort of high-risk cardiac surgery patients, preoperative urinary neutrophil gelatinase-associated lipocalin value provided prognostic information that was independent of the onset of acute kidney injury or of preoperative renal function.

Original languageEnglish
Pages (from-to)323-327
Number of pages5
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number2
Publication statusPublished - Apr 2014
Externally publishedYes


  • acute kidney injury
  • cardiac surgery
  • intensive care
  • neutrophil gelatinase-associated lipocalin

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