Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase

William J. Mckinstry; Aaron J. Oakley; Jamie Rossjohn; Denis Verger; Kian Leong Tan; Philip G. Board; Michael W. Parker

doi:10.1107/S0907444997008366

Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase

William J. Mckinstry, Aaron J. Oakley, Jamie Rossjohn, Denis Verger, Kian Leong Tan, Philip G. Board, Michael W. Parker

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3₁21 with cell dimensions of a= b = 94.0 and c = 120.5 Å. They contain two monomers in the asymmetric unit and diffract to 3.0 Å resolution.

Original language	English
Pages (from-to)	148-150
Number of pages	3
Journal	Acta Crystallographica Section D: Biological Crystallography
Volume	54
Issue number	1
DOIs	https://doi.org/10.1107/S0907444997008366
Publication status	Published - 1 Jan 1998
Externally published	Yes

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abstract = "Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a= b = 94.0 and c = 120.5 {\AA}. They contain two monomers in the asymmetric unit and diffract to 3.0 {\AA} resolution.",

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AU - Mckinstry, William J.

AU - Oakley, Aaron J.

AU - Rossjohn, Jamie

AU - Verger, Denis

AU - Tan, Kian Leong

AU - Board, Philip G.

AU - Parker, Michael W.

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AB - Human theta-class glutathione S-transferases (GST's) appear to play a critical role in the metabolism of a variety of environmental pollutants but in some cases the products of the reaction are carcinogenic. Crystals of a human theta-class GST, namely hGSTT2-2, have been grown from polyethylene glycol by the hanging-drop vapour-diffusion method. The crystals belong to the trigonal space group P3121 with cell dimensions of a= b = 94.0 and c = 120.5 Å. They contain two monomers in the asymmetric unit and diffract to 3.0 Å resolution.

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Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase

Abstract

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