Preimplantation genetic testing for aneuploidy: are we examining the correct outcomes?

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Abstract

Questions continue to be raised regarding the benefit of genetic assessment of embryos prior to transfer in IVF, specifically with regards to preimplantation genetic testing for aneuploidy (PGT-A). To evaluate and quantify these concerns, we appraised the most recent (2012-2019) randomized controlled trials on the topic. Only two of these six studies listed cumulative live birth rates per started cycle, with both eliciting a statistically non-significant result. This article describes the concern that a focus on results from the first embryo transfer compared to cumulative outcomes falsely construes PGT-A as having superior outcomes, whilst its true benefit is not confirmed, and it cannot actually improve the true pregnancy outcome of an embryo pool.

Original languageEnglish
Pages (from-to)2408-2412
Number of pages5
JournalHuman Reproduction
Volume35
Issue number11
DOIs
Publication statusPublished - 1 Nov 2020

Keywords

  • cumulative outcomes
  • embryo
  • IVF
  • outcomes
  • PGT-A
  • RCTs

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