@article{eaa4239d923743a4b12e38abda037380,
title = "Pregnancy outcomes in women with surgically treated epilepsy",
abstract = "Objective: To ascertain whether epileptic seizure control during pregnancy differed between Australian women with previously surgically treated epilepsy, and those with only medically treated epilepsy. Materials/Methods: Analysis of data for 74 pregnancies of women with surgically treated focal epilepsy, compared with that from 1013 pregnancies in women with medically treated focal epilepsy, both groups drawn from the Australian Register of Antiepileptic Drugs in Pregnancy between 1999 and 2020. Results: Seizures of all types, and also convulsive seizures, were less well controlled during pregnancy in the previously surgically treated cases, the difference for seizures of all types (68.9% versus 50.1%) being statistically significant (p <.05). This result was contrary to the outcome of a previously published study of the same question carried out in India. Conclusions: At present, it may be premature to conclude that previous epilepsy surgery will be associated with a better chance of seizure-free, or seizure-controlled, pregnancy.",
keywords = "antiepileptic drugs, epilepsy, pregnancy, seizure, surgery",
author = "Vajda, {Frank J.E.} and O{\textquoteright}Brien, {Terence J.} and Graham, {Janet E.} and Hitchcock, {Alison A.} and Lander, {Cecilie M.} and Eadie, {Mervyn J.}",
note = "Funding Information: We acknowledge the help provided by professional and lay colleagues who referred patients to the Australian Pregnancy Register (APR), and wish to thank the Scientific Advisory Board and the Ethical Research Committees of St. Vincent's Hospital, Monash Medical Centre, the Royal Melbourne Hospital, and other institutions for their continuing ethics oversight of the APR. The Register is grateful for support from the Epilepsy Society of Australia, The Royal Melbourne Hospital Neuroscience Foundation, Epilepsy Action, and financial assistance from the National Health and Medical Research Council, and the pharmaceutical companies Sanofi‐Aventis, Genzyme, UCB Pharma, Sci‐Gen and Eisai. Funding Information: FJE Vajda has received research support for the Australian Pregnancy Register from the Epilepsy Society of Australia, NHMRC, RMH Neuroscience Foundation, Epilepsy Action, Sanofi‐Aventis, Eisai, UCB Pharma and Sci‐Gen. T O{\textquoteright}Brien has received research support from the Epilepsy Society of Australia, NHMRC, RMH Neuroscience Foundation, Sanofi‐Aventis, UCB Pharma, and Sci‐Gen and Eisai. JE Graham, AA Hitchcock, CM Lander and MJ Eadie have no relevant conflicts of interest to declare. Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = nov,
doi = "10.1111/ane.13499",
language = "English",
volume = "144",
pages = "473–477",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "5",
}