Prefrontal Modulation of Visual Processing and Sustained Attention in Aging, a tDCS–EEG Coregistration Approach

Meadhbh B. Brosnan, Mahnaz Arvaneh, Siobhán Harty, Tara Maguire, Redmond O'Connell, Ian Robertson, Paul Dockree

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The ability to sustain attention is integral to healthy cognition in aging. The right PFC (rPFC) is critical for maintaining high levels of attentional focus. Whether plasticity of this region can be harnessed to support sustained attention in older adults is unknown. We used transcranial direct current stimulation to in- crease cortical excitability of the rPFC, while monitoring behav- ioral and electrophysiological markers of sustained attention in older adults with suboptimal sustained attention capacity. During rPFC transcranial direct current stimulation, fewer lapses of attention occurred and electroencephalography signals of frontal engagement and early visual attention were enhanced. To further verify these results, we repeated the experiment in an indepen- dent cohort of cognitively typical older adults using a different sustained attention paradigm. Again, prefrontal stimulation was associated with fewer attentional lapses. These experiments suggest the rPFC can be manipulated in later years to increase top–down modulation over early sensory processing and im- prove sustained attention performance. This holds valuable information for the development of neurorehabilitation proto- cols to ameliorate age-related deficits in this capacity
Original languageEnglish
Pages (from-to)1630-1645
Number of pages16
JournalJournal of Cognitive Neuroscience
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 2018

Cite this