Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 9938 - 9943 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences |
| Volume | 110 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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Prefrontal microcircuit underlies contextual learning after hippocampal loss. / Zelikowsky, Moriel; Bissiere, Stephanie; Hast, Timothy A; Bennett, Rebecca Z; Abdipranoto, Andrea; Vissel, Bryce; Fanselow, Michael S.
In: Proceedings of the National Academy of Sciences, Vol. 110, No. 24, 2013, p. 9938 - 9943.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Prefrontal microcircuit underlies contextual learning after hippocampal loss
AU - Zelikowsky, Moriel
AU - Bissiere, Stephanie
AU - Hast, Timothy A
AU - Bennett, Rebecca Z
AU - Abdipranoto, Andrea
AU - Vissel, Bryce
AU - Fanselow, Michael S
PY - 2013
Y1 - 2013
N2 - Specific brain circuits have been classically linked to dedicated functions. However, compensation following brain damage suggests that these circuits are capable of dynamic adaptation. Such compensation is exemplified by Pavlovian fear conditioning following damage to the dorsal hippocampus (DH). Although the DH normally underlies contextual fear and fear renewal after extinction, both can be learned in the absence of the DH, although the mechanisms and nature of this compensation are currently unknown. Here, we report that recruitment of alternate structures, specifically the infralimbic and prelimbic prefrontal cortices, is required for compensation following damage to the hippocampus. Disconnection of these cortices in DH-compromised animals and immediate early gene induction profiles for amygdala-projecting prefrontal cells revealed that communication and dynamic rebalancing within this prefrontal microcircuit is critical. Additionally, the infralimbic cortex normally plays a role in limiting generalization of contextual fear. These discoveries reveal that plasticity through recruitment of alternate circuits allows the brain to compensate following damage, offering promise for targeted treatment of memory disorders.
AB - Specific brain circuits have been classically linked to dedicated functions. However, compensation following brain damage suggests that these circuits are capable of dynamic adaptation. Such compensation is exemplified by Pavlovian fear conditioning following damage to the dorsal hippocampus (DH). Although the DH normally underlies contextual fear and fear renewal after extinction, both can be learned in the absence of the DH, although the mechanisms and nature of this compensation are currently unknown. Here, we report that recruitment of alternate structures, specifically the infralimbic and prelimbic prefrontal cortices, is required for compensation following damage to the hippocampus. Disconnection of these cortices in DH-compromised animals and immediate early gene induction profiles for amygdala-projecting prefrontal cells revealed that communication and dynamic rebalancing within this prefrontal microcircuit is critical. Additionally, the infralimbic cortex normally plays a role in limiting generalization of contextual fear. These discoveries reveal that plasticity through recruitment of alternate circuits allows the brain to compensate following damage, offering promise for targeted treatment of memory disorders.
UR - http://www.pnas.org/content/110/24/9938.full.pdf
U2 - 10.1073/pnas.1301691110
DO - 10.1073/pnas.1301691110
M3 - Article
VL - 110
SP - 9938
EP - 9943
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 24
ER -