Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors

Louise C. Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J. D'Orsogna, Thi H.O. Nguyen, Frans H.J. Claas, Jamie Rossjohn, Tom C. Kotsimbos, Anthony W. Purcell, Nicole A. Mifsud

Research output: Contribution to journalArticleResearchpeer-review

Abstract

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8+ T cells directed against peptides derived from chronic viruses (EBV, CMV, and HIV-1) presented by high frequency HLA-A and -B allomorphs differentially cross-react toward HLA-B27 allotypes in a highly focused and hierarchical manner. Given the commonality of cross-reactive T cells and their potential contribution to adverse outcomes in allogeneic transplants, our study demonstrates that multiple antiviral T cells recognizing the same HLA allomorph could pose an extra layer of complexity for organ matching.

Original languageEnglish
Article number248
Number of pages13
JournalFrontiers in Immunology
Volume11
DOIs
Publication statusPublished - 19 Feb 2020

Keywords

  • CMV
  • cross-reactivity
  • EBV
  • HIV-1
  • HLA
  • T cells
  • TCR

Cite this