Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?

Sidonia BG Eckle, Stephen J Turner, Jamie Rossjohn, James McCluskey

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily related Ag-presenting molecules present peptides, lipids and vitamin B metabolites for T cell surveillance. Interestingly, whilst common TCR gene usage can underpin recognition of these distinct classes of Ags, it is unclear whether the 'rules' that govern αβTCR-Ag MHC interactions are shared. We highlight recent observations in the context of TCR biases towards MHC and MHC-I like molecules.

Original languageEnglish
Pages (from-to)653-659
Number of pages7
JournalCurrent Opinion in Immunology
Volume25
Issue number5
DOIs
Publication statusPublished - Oct 2013

Cite this

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title = "Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?",
abstract = "The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily related Ag-presenting molecules present peptides, lipids and vitamin B metabolites for T cell surveillance. Interestingly, whilst common TCR gene usage can underpin recognition of these distinct classes of Ags, it is unclear whether the 'rules' that govern αβTCR-Ag MHC interactions are shared. We highlight recent observations in the context of TCR biases towards MHC and MHC-I like molecules.",
author = "Eckle, {Sidonia BG} and Turner, {Stephen J} and Jamie Rossjohn and James McCluskey",
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Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules? / Eckle, Sidonia BG; Turner, Stephen J; Rossjohn, Jamie; McCluskey, James.

In: Current Opinion in Immunology, Vol. 25, No. 5, 10.2013, p. 653-659.

Research output: Contribution to journalReview ArticleOtherpeer-review

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