Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

Sarah J Tabrizi; Rachael I Scahill; Gail N Owen; Alexandra Durr; Blair R Leavitt; Raymund A C Roos; Beth Borowsky; Bernhard Landwehrmeyer; Chris Frost; Hans Johnson; David O Craufurd; Ralph Reilmann; Julie C Stout; Douglas R Langbehn

doi:10.1016/S1474-4422(13)70088-7

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

Sarah J Tabrizi, Rachael I Scahill, Gail N Owen, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Beth Borowsky, Bernhard Landwehrmeyer, Chris Frost, Hans Johnson, David O Craufurd, Ralph Reilmann, Julie C Stout, Douglas R Langbehn

School of Psychological Sciences

Research output: Contribution to journal › Article › Research › peer-review

653 Citations (Scopus)

Abstract

TRACK-HD is a multinational prospective observational study of Huntington s disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression.

Original language	English
Pages (from-to)	637 - 649
Number of pages	13
Journal	The Lancet Neurology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/S1474-4422(13)70088-7
Publication status	Published - 2013

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10.1016/S1474-4422(13)70088-7

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Tabrizi, S. J., Scahill, R. I., Owen, G. N., Durr, A., Leavitt, B. R., Roos, R. A. C., Borowsky, B., Landwehrmeyer, B., Frost, C., Johnson, H., Craufurd, D. O., Reilmann, R., Stout, J. C., & Langbehn, D. R. (2013). Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. The Lancet Neurology, 12(7), 637 - 649. https://doi.org/10.1016/S1474-4422(13)70088-7

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title = "Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data",

abstract = "TRACK-HD is a multinational prospective observational study of Huntington s disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression.",

author = "Tabrizi, {Sarah J} and Scahill, {Rachael I} and Owen, {Gail N} and Alexandra Durr and Leavitt, {Blair R} and Roos, {Raymund A C} and Beth Borowsky and Bernhard Landwehrmeyer and Chris Frost and Hans Johnson and Craufurd, {David O} and Ralph Reilmann and Stout, {Julie C} and Langbehn, {Douglas R}",

year = "2013",

doi = "10.1016/S1474-4422(13)70088-7",

language = "English",

volume = "12",

pages = "637 -- 649",

journal = "The Lancet Neurology",

issn = "1474-4422",

publisher = "Elsevier",

number = "7",

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Tabrizi, SJ, Scahill, RI, Owen, GN, Durr, A, Leavitt, BR, Roos, RAC, Borowsky, B, Landwehrmeyer, B, Frost, C, Johnson, H, Craufurd, DO, Reilmann, R, Stout, JC & Langbehn, DR 2013, 'Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data', The Lancet Neurology, vol. 12, no. 7, pp. 637 - 649. https://doi.org/10.1016/S1474-4422(13)70088-7

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. / Tabrizi, Sarah J; Scahill, Rachael I; Owen, Gail N et al.
In: The Lancet Neurology, Vol. 12, No. 7, 2013, p. 637 - 649.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

AU - Tabrizi, Sarah J

AU - Scahill, Rachael I

AU - Owen, Gail N

AU - Durr, Alexandra

AU - Leavitt, Blair R

AU - Roos, Raymund A C

AU - Borowsky, Beth

AU - Landwehrmeyer, Bernhard

AU - Frost, Chris

AU - Johnson, Hans

AU - Craufurd, David O

AU - Reilmann, Ralph

AU - Stout, Julie C

AU - Langbehn, Douglas R

PY - 2013

Y1 - 2013

N2 - TRACK-HD is a multinational prospective observational study of Huntington s disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression.

AB - TRACK-HD is a multinational prospective observational study of Huntington s disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression.

UR - http://www.sciencedirect.com/science/article/pii/S1474442213700887

U2 - 10.1016/S1474-4422(13)70088-7

DO - 10.1016/S1474-4422(13)70088-7

M3 - Article

SN - 1474-4422

VL - 12

SP - 637

EP - 649

JO - The Lancet Neurology

JF - The Lancet Neurology

IS - 7

ER -

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

Abstract

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