Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

Sarah J Tabrizi, Rachael I Scahill, Gail N Owen, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Beth Borowsky, Bernhard Landwehrmeyer, Chris Frost, Hans Johnson, David O Craufurd, Ralph Reilmann, Julie C Stout, Douglas R Langbehn

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Abstract

TRACK-HD is a multinational prospective observational study of Huntington s disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression.
Original languageEnglish
Pages (from-to)637 - 649
Number of pages13
JournalThe Lancet Neurology
Volume12
Issue number7
DOIs
Publication statusPublished - 2013

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