TY - JOUR
T1 - Predictors of major depression and posttraumatic stress disorder following traumatic brain injury
T2 - A systematic review and meta-analysis
AU - Cnossen, Maryse C.
AU - Scholten, Annemieke C.
AU - Lingsma, Hester F.
AU - Synnot, Anneliese
AU - Haagsma, Juanita A
AU - Steyerberg, Ewout W
AU - Polinder, Suzanne
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Although major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are prevalent after traumatic brain injury (TBI), little is known about which patients are at risk for developing them. The authors systematically reviewed the literature on predictors and multivariable models for MDD and PTSD after TBI. The authors included 26 observational studies. MDD was associated with female gender, preinjury depression, postinjury unemployment, and lower brain volume, whereas PTSD was related to shorter posttraumatic amnesia, memory of the traumatic event, and early posttraumatic symptoms. Risk of bias ratings for most studies were acceptable, although studies that developed a multivariable model suffered from methodological shortcomings.
AB - Although major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are prevalent after traumatic brain injury (TBI), little is known about which patients are at risk for developing them. The authors systematically reviewed the literature on predictors and multivariable models for MDD and PTSD after TBI. The authors included 26 observational studies. MDD was associated with female gender, preinjury depression, postinjury unemployment, and lower brain volume, whereas PTSD was related to shorter posttraumatic amnesia, memory of the traumatic event, and early posttraumatic symptoms. Risk of bias ratings for most studies were acceptable, although studies that developed a multivariable model suffered from methodological shortcomings.
UR - http://www.scopus.com/inward/record.url?scp=85022059363&partnerID=8YFLogxK
U2 - 10.1176/appi.neuropsych.16090165
DO - 10.1176/appi.neuropsych.16090165
M3 - Review Article
AN - SCOPUS:85022059363
SN - 0895-0172
VL - 29
SP - 206
EP - 224
JO - The Journal of Neuropsychiatry and Clinical Neurosciences
JF - The Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -