Predictors of incident heart failure hospitalizations among patients with impaired glucose tolerance insight from the nateglinide and valsartan in impaired glucose tolerance outcomes research study

Yee Weng Wong, Laine Thomas, Jie-Lena Sun, John J V McMurray, Henry Krum, Adrian F Hernandez, Guy EHM Rutten, Lawrence A Leiter, Eberhard Standl, Steven Haffner, Theodore Mazzone, Felipe Martinez, Gianni Tognoni, Thomas Giles, Robert M Califf

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21 Citations (Scopus)


Impaired glucose tolerance and metabolic syndrome are associated with increased risk of heart failure (HF). However, predictors associated with the increased risk of incident HF have not been well characterized. We aimed to identify independent predictors of incident HF hospitalization among patients with impaired glucose tolerance. Methods and Results.In Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR), 9306 research participants with impaired glucose tolerance and .1 cardiovascular risk factors were randomized to valsartan versus placebo and nateglinide versus placebo in a 2-2 factorial manner, with a median follow-up of 6.5 years. Using a multivariable Cox proportional hazards model, we analyzed the relationships among baseline clinical factors and the outcome of incident HF hospitalization in patients without history of HF. Significant predictors were identified by forward selection. Increasing age, history of coronary heart disease, and atrial fibrillation or flutter were among several known independent predictors of incident HF hospitalization. Increased waist circumference (hazard ratio per 10 cm, 1.37; 95 confidence interval,; P
Original languageEnglish
Pages (from-to)203 - 210
Number of pages8
JournalCirculation: Heart Failure
Issue number2
Publication statusPublished - 2013

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