Predictors of erectile dysfunction after transperineal template prostate biopsy

Jo Lynn Tan, Nathan Papa, Uri Hanegbi, Ross Snow, Jeremy Grummet, Sarah Mann, Adam Cuthbertson, Mark Frydenberg, Daniel Moon

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Purpose: To investigate the incidence and possible contributing factors of erectile dysfunction (ED) after transperineal template prostate biopsy (TTPB). Materials and Methods: Males undergoing TTPB were prospectively administered a Sexual Health Inventory for Men (SHIM) ques-tionnaire before biopsy and one month after. SHIM questionnaires were repeated at 3-and 9-months for males not receiving inter-ventional treatment. Sexually inactive males were excluded. Interval change in SHIM categories based upon baseline characteristics were evaluated. Multivariable logistic regression models were used to evaluate predictors of change in SHIM score category. Results: A total of 576 males were included in our sample. Of these, 450 (78%) males underwent their first biopsy. A decline in SHIM category within the immediate 4-weeks post-biopsy was reported by 167 males (31% of total eligible sample). Age was the strongest predictor of decline in SHIM category, the predicted probability of a decline in SHIM at age 50 was 10% (95% confidence interval [CI], 1%–19%), 32% at age 60 (95% CI, 25%–40%) and 36% at age 70 (95% CI, 29%–44%). For new onset ED, the predicted probability of ED within 4-weeks post-TTPB were 6.7% at age 50 (95% CI, 0%–15%), 26% at age 60 (95% CI, 17%–34%) and 31% at age 70 (95% CI, 21%–40%). Conclusions: Older age at biopsy is an independent predictor of immediate ED after TTPB in sexually active males. This association was observed in the subgroup with no pre-existing ED. These findings provide useful information when counselling males undergoing TTPB.

Original languageEnglish
Pages (from-to)159-165
Number of pages7
JournalInvestigative and Clinical Urology
Issue number2
Publication statusPublished - Mar 2021


  • Erectile dysfunction
  • Prostate biopsy
  • Prostatic neoplasms

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