Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy

Rahayu Lubis; Awang Bulgiba; Adeeba Kamarulzaman; Noran N. Hairi; Maznah Dahlui; Devi Peramalah

doi:10.1016/j.ypmed.2013.01.006

Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy

Rahayu Lubis
, Awang Bulgiba
, Adeeba Kamarulzaman
, Noran N. Hairi
, Maznah Dahlui
, Devi Peramalah

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged ≥ 20. years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan-Meier and Cox regression analyses. Results: 72.7% of the patients survived. Multivariate Cox regression showed that significant predictors of death were age ≥ 50 years (HR 1.76; 95% CI 1.18-2.64), secondary education (HR 3.57; 95% CI 1.12-11.37), tertiary education (HR 3.57; 95% CI 1.09-11.70), being unemployed (HR 1.49; 95% CI 1.07-2.09), AIDS on initial presentation (HR 5.75; 95% CI 3.29-10.07), single-drug ART (HR 1.84; 95% CI 1.27, 2.66), double-drug ART (HR 1.63; 95% CI 1.19-2.25) and inability to achieve viral load ≤ 50. copies/ml (HR 10.22; 95% CI 7.26-14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to ≤ 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients.

Original language	English
Pages (from-to)	S54-S56
Number of pages	3
Journal	Preventive Medicine
Volume	57
Issue number	SUPPL
DOIs	https://doi.org/10.1016/j.ypmed.2013.01.006
Publication status	Published - 2013
Externally published	Yes
Event	Asia Pacific Clinical Epidemiology and Evidence Based Medicine Conference 2012 - Kuala Lumpu, Malaysia Duration: 6 Jul 2012 → 8 Jul 2012 Conference number: 1st https://www.sciencedirect.com/journal/preventive-medicine/vol/57/suppl/S

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-retroviral therapy
Death
HIV
Malaysian patients
Predictors
Survival

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10.1016/j.ypmed.2013.01.006

Cite this

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title = "Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy",

abstract = "Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged ≥ 20. years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan-Meier and Cox regression analyses. Results: 72.7\% of the patients survived. Multivariate Cox regression showed that significant predictors of death were age ≥ 50 years (HR 1.76; 95\% CI 1.18-2.64), secondary education (HR 3.57; 95\% CI 1.12-11.37), tertiary education (HR 3.57; 95\% CI 1.09-11.70), being unemployed (HR 1.49; 95\% CI 1.07-2.09), AIDS on initial presentation (HR 5.75; 95\% CI 3.29-10.07), single-drug ART (HR 1.84; 95\% CI 1.27, 2.66), double-drug ART (HR 1.63; 95\% CI 1.19-2.25) and inability to achieve viral load ≤ 50. copies/ml (HR 10.22; 95\% CI 7.26-14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to ≤ 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients.",

keywords = "Anti-retroviral therapy, Death, HIV, Malaysian patients, Predictors, Survival",

author = "Rahayu Lubis and Awang Bulgiba and Adeeba Kamarulzaman and Hairi, \{Noran N.\} and Maznah Dahlui and Devi Peramalah",

note = "Funding Information: This work is part of the IDM project (STeMM Programme) supported by the University of Malaya/Ministry of Higher Education (UM/MOHE) High Impact Research Grant (grant number E000010-20001 ) and the Fundamental Research Grant Scheme (FRGS) from the Ministry of Higher Education, Malaysia (grant FP080/2006A ).; Asia Pacific Clinical Epidemiology and Evidence Based Medicine Conference 2012 ; Conference date: 06-07-2012 Through 08-07-2012",

year = "2013",

doi = "10.1016/j.ypmed.2013.01.006",

language = "English",

volume = "57",

pages = "S54--S56",

journal = "Preventive Medicine",

issn = "0091-7435",

publisher = "Elsevier BV",

number = "SUPPL",

url = "https://www.sciencedirect.com/journal/preventive-medicine/vol/57/suppl/S",

}

TY - JOUR

T1 - Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy

AU - Lubis, Rahayu

AU - Bulgiba, Awang

AU - Kamarulzaman, Adeeba

AU - Hairi, Noran N.

AU - Dahlui, Maznah

AU - Peramalah, Devi

N1 - Conference code: 1st

PY - 2013

Y1 - 2013

N2 - Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged ≥ 20. years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan-Meier and Cox regression analyses. Results: 72.7% of the patients survived. Multivariate Cox regression showed that significant predictors of death were age ≥ 50 years (HR 1.76; 95% CI 1.18-2.64), secondary education (HR 3.57; 95% CI 1.12-11.37), tertiary education (HR 3.57; 95% CI 1.09-11.70), being unemployed (HR 1.49; 95% CI 1.07-2.09), AIDS on initial presentation (HR 5.75; 95% CI 3.29-10.07), single-drug ART (HR 1.84; 95% CI 1.27, 2.66), double-drug ART (HR 1.63; 95% CI 1.19-2.25) and inability to achieve viral load ≤ 50. copies/ml (HR 10.22; 95% CI 7.26-14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to ≤ 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients.

AB - Objective: To determine the predictors of death in Malaysian HIV-infected patients undergoing antiretroviral therapy (ART). Methods: Data from 845 HIV-infected patients aged ≥ 20. years on ART in a large teaching hospital in Malaysia from 1989 to 2009 were analyzed using Kaplan-Meier and Cox regression analyses. Results: 72.7% of the patients survived. Multivariate Cox regression showed that significant predictors of death were age ≥ 50 years (HR 1.76; 95% CI 1.18-2.64), secondary education (HR 3.57; 95% CI 1.12-11.37), tertiary education (HR 3.57; 95% CI 1.09-11.70), being unemployed (HR 1.49; 95% CI 1.07-2.09), AIDS on initial presentation (HR 5.75; 95% CI 3.29-10.07), single-drug ART (HR 1.84; 95% CI 1.27, 2.66), double-drug ART (HR 1.63; 95% CI 1.19-2.25) and inability to achieve viral load ≤ 50. copies/ml (HR 10.22; 95% CI 7.26-14.37). Conclusion: Every effort needs to be made to ensure that all HIV patients have access to triple drug ART, to lower viral load to ≤ 50 copies/ml and to treat HIV patients before they progress to AIDS as these are significant modifiable predictors of death in Malaysian HIV patients.

KW - Anti-retroviral therapy

KW - Death

KW - HIV

KW - Malaysian patients

KW - Predictors

KW - Survival

UR - https://www.scopus.com/pages/publications/84880579071

U2 - 10.1016/j.ypmed.2013.01.006

DO - 10.1016/j.ypmed.2013.01.006

M3 - Article

C2 - 23352555

AN - SCOPUS:84880579071

SN - 0091-7435

VL - 57

SP - S54-S56

JO - Preventive Medicine

JF - Preventive Medicine

IS - SUPPL

T2 - Asia Pacific Clinical Epidemiology and Evidence Based Medicine Conference 2012

Y2 - 6 July 2012 through 8 July 2012

ER -

Predictors of death in Malaysian HIV-infected patients on anti-retroviral therapy

Abstract

UN SDGs

Keywords

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