Predictors of Death after Clostridium difficile Infection: A Report on 128 Strain-Typed Cases from a Teaching Hospital in the United Kingdom

Vhairi Wilson; Liz Cheek; Giovanni Satta; Karen Walker-Bone; Marc Cubbon; Diane Citron; Dale N. Gerding; Martin J. Llewelyn

doi:10.1086/653012

Predictors of Death after Clostridium difficile Infection: A Report on 128 Strain-Typed Cases from a Teaching Hospital in the United Kingdom

Vhairi Wilson, Liz Cheek, Giovanni Satta, Karen Walker-Bone, Marc Cubbon, Diane Citron, Dale N. Gerding, Martin J. Llewelyn

Research output: Contribution to journal › Article › Research › peer-review

66 Citations (Scopus)

Abstract

We assessed the relationship between strain type, clinical factors, and outcome in 128 patients with Clostridium difficile infection. Strain type was not associated with any outcome measure. On multivariate analysis, ischemic heart disease and hypoalbuminemia predicted death. Metronidazole treatment in severe disease was associated with a higher rate of treatment failure and death.

Original language	English
Pages (from-to)	e77-e81
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	50
Issue number	12
DOIs	https://doi.org/10.1086/653012
Publication status	Published - 15 Jun 2010
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1086/653012

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title = "Predictors of Death after Clostridium difficile Infection: A Report on 128 Strain-Typed Cases from a Teaching Hospital in the United Kingdom",

abstract = "We assessed the relationship between strain type, clinical factors, and outcome in 128 patients with Clostridium difficile infection. Strain type was not associated with any outcome measure. On multivariate analysis, ischemic heart disease and hypoalbuminemia predicted death. Metronidazole treatment in severe disease was associated with a higher rate of treatment failure and death.",

author = "Vhairi Wilson and Liz Cheek and Giovanni Satta and Karen Walker-Bone and Marc Cubbon and Diane Citron and Gerding, \{Dale N.\} and Llewelyn, \{Martin J.\}",

note = "Funding Information: Financial support. The costs of C. difficile culture and typing of isolates in this study were met by grants from Optimer Pharmaceuticals (to D.C. and D.N.G.) and the US Department of Veterans Affairs Research Service (through a grant to D.N.G.).",

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AU - Wilson, Vhairi

AU - Cheek, Liz

AU - Satta, Giovanni

AU - Walker-Bone, Karen

AU - Cubbon, Marc

AU - Citron, Diane

AU - Gerding, Dale N.

AU - Llewelyn, Martin J.

N1 - Funding Information: Financial support. The costs of C. difficile culture and typing of isolates in this study were met by grants from Optimer Pharmaceuticals (to D.C. and D.N.G.) and the US Department of Veterans Affairs Research Service (through a grant to D.N.G.).

PY - 2010/6/15

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N2 - We assessed the relationship between strain type, clinical factors, and outcome in 128 patients with Clostridium difficile infection. Strain type was not associated with any outcome measure. On multivariate analysis, ischemic heart disease and hypoalbuminemia predicted death. Metronidazole treatment in severe disease was associated with a higher rate of treatment failure and death.

AB - We assessed the relationship between strain type, clinical factors, and outcome in 128 patients with Clostridium difficile infection. Strain type was not associated with any outcome measure. On multivariate analysis, ischemic heart disease and hypoalbuminemia predicted death. Metronidazole treatment in severe disease was associated with a higher rate of treatment failure and death.

UR - https://www.scopus.com/pages/publications/77953002541

U2 - 10.1086/653012

DO - 10.1086/653012

M3 - Article

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JF - Clinical Infectious Diseases

IS - 12

ER -

Predictors of Death after Clostridium difficile Infection: A Report on 128 Strain-Typed Cases from a Teaching Hospital in the United Kingdom

Abstract

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