Predictors for sustained new-onset atrial fibrillation in critically ill patients: a retrospective observational study

Taisuke Yokota, Shigehiko Uchino, Takuo Yoshida, Tomoko Fujii, Masanori Takinami

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3 Citations (Scopus)

Abstract

Purpose: Although new-onset atrial fibrillation (AF) is frequently observed in the intensive care unit (ICU), the incidence and predictors for sustained new-onset AF have not been investigated, except for cardiac surgery patients. We have evaluated potential predictors for sustained new-onset AF in a mixed ICU. Methods: In this retrospective observational study, we screened non-cardiac surgery patients who were admitted to the ICU between January 2010 and December 2013 and had been hospitalized for > 24 h in the ICU. We collected information about heart rhythm 6 h after the onset of AF. We compared detailed patient characteristics between patients with sinus rhythm (SR) and those with sustained AF at 6 h after the onset of AF. Additionally, we applied variable selection using backward elimination based on Akaike’s Information Criterion (AIC). Calibration was performed based on the Hosmer–Lemeshow test. Results: New-onset AF occurred in 151 of 1718 patients and 99 patients converted to SR at 6 h. Backward elimination identified predictors as follows (AIC = 175.3): CHADS 2 score, elective surgery, infection on ICU admission, serum potassium > 4.0 mmol/L, male sex, mechanical ventilation, and diagnostic grouping. The model showed good calibration for sustenance of AF at 6 h after the onset using the Hosmer–Lemeshow Chi-square value of 4.36 (degrees of freedom = 4, p = 0.360) indicating a good fit. Conclusions: These predictors might be useful in future interventional studies to identify patients who are likely to sustain new-onset AF.

Original languageEnglish
Pages (from-to)681-687
Number of pages7
JournalJournal of Anesthesia
Volume32
Issue number5
DOIs
Publication statusPublished - 1 Oct 2018
Externally publishedYes

Keywords

  • AF at 6 h after onset
  • Critically ill patients
  • Predictors
  • Sinus rhythm
  • Sustained new-onset AF

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