Voorspellen van dreigende vroeggeboorte door middel van bepaling van foetaal fibronectine in vaginaal vocht

Translated title of the contribution: Prediction of threatened premature birth by determination of fetal fibronectin in vaginal fluid

Femke F. Wilms, Giel Van Stralen, Martina M. Porath, Dimitri N.M. Papatsonis, S. Guid Oei, Ben Willem Mol, Sicco Scherjo

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


To determine the prognostic value of foetal fibronectin and cervical length for predicting imminent preterm labour among Dutch women, who in the Netherlands normally undergo a digital examination of the cervix prior to referral to a hospital or university medical centre. Prospective observational cohort study. Pregnant women with symptoms of preterm labour and a gestational age between 24 and 34 weeks were included. A fibronectin smear was taken from them and the cervical length was measured. Primary outcome was delivery within 7 days after inclusion. Sensitivity, specificity and a receiver-operating characteristics (ROC) curve were calculated. 13 (12%) of the 108 included patients delivered spontaneously within 7 days after inclusion. The fibronectin test had a sensitivity of 92% and specificity of 60%. The positive and negative predictive values were 27% and 98% respectively. For women who had undergone a digital examination prior to testing, the predictive value was slightly less but the difference was not significant. Although measurement of the cervical length scarcely had a predictive value, none of the patients with a cervical length above 35 mm delivered within 7 days. In women with an imminent preterm labour, a negative fibronectin test virtually ruled out delivery within 7 days. The fibronectin test can therefore also be used in the Dutch situation. In women with a cervix length greater than 35 mm, the chance of a preterm labour within 7 days is very small and a fibronectin test does not need to be performed in their case.

Translated title of the contributionPrediction of threatened premature birth by determination of fetal fibronectin in vaginal fluid
Original languageDutch
Pages (from-to)1514-1520
Number of pages7
JournalNederlands Tijdschrift voor Geneeskunde
Issue number31
Publication statusPublished - 1 Aug 2009
Externally publishedYes

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