Prediction of the hazard of foetal malformation in pregnant women with epilepsy

F. J E Vajda, T. J. O'Brien, J. Graham, C. M. Lander, M. J. Eadie

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

The data collected in the Australian Register of antiepileptic drugs in pregnancy have been studied in the hope of defining simple items of information that could be recorded at initial interview of pregnant women with epilepsy, and which might allow estimation of the risk of the pregnancy resulting in a malformed foetus. Analysis of the data showed that dose of valproate, but not intake of other commonly used antiepileptic drugs, in the current pregnancy, and a past history of a pregnancy involving a malformed foetus, statistically significantly increased the malformation hazard in the current pregnancy, and that continuing alcohol intake might decrease it. Plotting the hazard against valproate dose in monotherapy, with or without histories of (i) previous pregnancies with foetal malformations (FMs), and (ii) continuing alcohol intake, provided quantitative information concerning the degree of increased risk. It is hoped that this information may help in advising about the risk of foetal malformation (FM) in individual pregnancies.

Original languageEnglish
Pages (from-to)1013-1017
Number of pages5
JournalEpilepsy Research
Volume108
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Alcohol
  • Antiepileptic drugs
  • Foetal malformations
  • Spina bifida
  • Teratogenesis
  • Valproate

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