Predicting tablet strength from the wet granulation conditions via the unified compaction curve

Thanh H. Nguyen, David A.V. Morton, Karen Hapgood

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

1 Citation (Scopus)

Abstract

Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50% microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].
Original languageEnglish
Title of host publicationProcedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7)
EditorsWei Ge, Yongsheng Han, Junwu Wang, Limin Wang, Xinjua Liu, Jiamao Zhou, Jinghai Li
Place of PublicationAmsterdam Netherlands
PublisherElsevier
Pages517 - 526
Number of pages10
Volume102
ISBN (Electronic)1877-7058
DOIs
Publication statusPublished - 2015
EventWorld Congress on Particle Technology (WCPT) 2014 - Beijing, China
Duration: 19 May 201422 May 2014
Conference number: 7th

Conference

ConferenceWorld Congress on Particle Technology (WCPT) 2014
Abbreviated titleWCPT 2014
CountryChina
CityBeijing
Period19/05/1422/05/14

Cite this

Nguyen, T. H., Morton, D. A. V., & Hapgood, K. (2015). Predicting tablet strength from the wet granulation conditions via the unified compaction curve. In W. Ge, Y. Han, J. Wang, L. Wang, X. Liu, J. Zhou, & J. Li (Eds.), Procedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7) (Vol. 102, pp. 517 - 526). Amsterdam Netherlands: Elsevier. https://doi.org/10.1016/j.proeng.2015.01.203
Nguyen, Thanh H. ; Morton, David A.V. ; Hapgood, Karen. / Predicting tablet strength from the wet granulation conditions via the unified compaction curve. Procedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7). editor / Wei Ge ; Yongsheng Han ; Junwu Wang ; Limin Wang ; Xinjua Liu ; Jiamao Zhou ; Jinghai Li. Vol. 102 Amsterdam Netherlands : Elsevier, 2015. pp. 517 - 526
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abstract = "Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50{\%} microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].",
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editor = "Wei Ge and Yongsheng Han and Junwu Wang and Limin Wang and Xinjua Liu and Jiamao Zhou and Jinghai Li",
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Nguyen, TH, Morton, DAV & Hapgood, K 2015, Predicting tablet strength from the wet granulation conditions via the unified compaction curve. in W Ge, Y Han, J Wang, L Wang, X Liu, J Zhou & J Li (eds), Procedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7). vol. 102, Elsevier, Amsterdam Netherlands, pp. 517 - 526, World Congress on Particle Technology (WCPT) 2014, Beijing, China, 19/05/14. https://doi.org/10.1016/j.proeng.2015.01.203

Predicting tablet strength from the wet granulation conditions via the unified compaction curve. / Nguyen, Thanh H.; Morton, David A.V.; Hapgood, Karen.

Procedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7). ed. / Wei Ge; Yongsheng Han; Junwu Wang; Limin Wang; Xinjua Liu; Jiamao Zhou; Jinghai Li. Vol. 102 Amsterdam Netherlands : Elsevier, 2015. p. 517 - 526.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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N2 - Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50% microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].

AB - Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50% microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].

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BT - Procedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7)

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Nguyen TH, Morton DAV, Hapgood K. Predicting tablet strength from the wet granulation conditions via the unified compaction curve. In Ge W, Han Y, Wang J, Wang L, Liu X, Zhou J, Li J, editors, Procedia Engineering: Proceedings of The 7th World Congress on Particle Technology (WCPT7). Vol. 102. Amsterdam Netherlands: Elsevier. 2015. p. 517 - 526 https://doi.org/10.1016/j.proeng.2015.01.203