Predicting tablet strength from the wet granulation conditions via the unified compaction curve

Thanh H. Nguyen; David A.V. Morton; Karen Hapgood

doi:10.1016/j.proeng.2015.01.203

Predicting tablet strength from the wet granulation conditions via the unified compaction curve

Thanh H. Nguyen, David A.V. Morton, Karen Hapgood

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

5 Citations (Scopus)

Abstract

Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50% microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].

Original language	English
Title of host publication	New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology
Editors	Wei Ge, Yongsheng Han, Junwu Wang, Limin Wang, Xinjua Liu, Jiamao Zhou, Jinghai Li
Place of Publication	Amsterdam Netherlands
Publisher	Elsevier
Pages	517 - 526
Number of pages	10
DOIs	https://doi.org/10.1016/j.proeng.2015.01.203
Publication status	Published - 2015
Event	World Congress on Particle Technology (WCPT) 2014 - Beijing, China Duration: 19 May 2014 → 22 May 2014 Conference number: 7th

Publication series

Name	Procedia Engineering
Publisher	Elsevier
Volume	102
ISSN (Electronic)	1877-7058

Conference

Conference	World Congress on Particle Technology (WCPT) 2014
Abbreviated title	WCPT 2014
Country/Territory	China
City	Beijing
Period	19/05/14 → 22/05/14

Access to Document

10.1016/j.proeng.2015.01.203

Cite this

Nguyen, T. H., Morton, D. A. V., & Hapgood, K. (2015). Predicting tablet strength from the wet granulation conditions via the unified compaction curve. In W. Ge, Y. Han, J. Wang, L. Wang, X. Liu, J. Zhou, & J. Li (Eds.), New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology (pp. 517 - 526). (Procedia Engineering; Vol. 102). Elsevier. https://doi.org/10.1016/j.proeng.2015.01.203

Nguyen, Thanh H. ; Morton, David A.V. ; Hapgood, Karen. / Predicting tablet strength from the wet granulation conditions via the unified compaction curve. New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology. editor / Wei Ge ; Yongsheng Han ; Junwu Wang ; Limin Wang ; Xinjua Liu ; Jiamao Zhou ; Jinghai Li. Amsterdam Netherlands : Elsevier, 2015. pp. 517 - 526 (Procedia Engineering).

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title = "Predicting tablet strength from the wet granulation conditions via the unified compaction curve",

abstract = "Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50% microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].",

author = "Nguyen, {Thanh H.} and Morton, {David A.V.} and Karen Hapgood",

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booktitle = "New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology",

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note = "World Congress on Particle Technology (WCPT) 2014, WCPT 2014 ; Conference date: 19-05-2014 Through 22-05-2014",

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Nguyen, TH, Morton, DAV & Hapgood, K 2015, Predicting tablet strength from the wet granulation conditions via the unified compaction curve. in W Ge, Y Han, J Wang, L Wang, X Liu, J Zhou & J Li (eds), New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology. Procedia Engineering, vol. 102, Elsevier, Amsterdam Netherlands, pp. 517 - 526, World Congress on Particle Technology (WCPT) 2014, Beijing, China, 19/05/14. https://doi.org/10.1016/j.proeng.2015.01.203

Predicting tablet strength from the wet granulation conditions via the unified compaction curve. / Nguyen, Thanh H.; Morton, David A.V.; Hapgood, Karen.
New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology. ed. / Wei Ge; Yongsheng Han; Junwu Wang; Limin Wang; Xinjua Liu; Jiamao Zhou; Jinghai Li. Amsterdam Netherlands: Elsevier, 2015. p. 517 - 526 (Procedia Engineering; Vol. 102).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AB - Tablets make up approximately one third of all drug dosage forms which makes tablet manufacture a common process in the pharmaceutical industry. The unified compaction curve [1] is a model developed initially to look at the impact of the roller compaction conditions on the tablet strength. The tensile strength of the tablets made from formulations containing at least 50% microcrystalline cellulose produced at roller compaction pressures were measured and the profiles were collapsed into a single master “unified compaction curve” (UCC). This allowed for the tablet strength to be predicted from the roller compaction condition and formulations and target the required tablet strength criterion set by standards or specifications [1].

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DO - 10.1016/j.proeng.2015.01.203

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Nguyen TH, Morton DAV, Hapgood K. Predicting tablet strength from the wet granulation conditions via the unified compaction curve. In Ge W, Han Y, Wang J, Wang L, Liu X, Zhou J, Li J, editors, New Paradigm of Particle Science and Technology Proceedings of The 7th World Congress on Particle Technology. Amsterdam Netherlands: Elsevier. 2015. p. 517 - 526. (Procedia Engineering). doi: 10.1016/j.proeng.2015.01.203