The beta-barrel is a ubiquitous fold that is deployed to accomplish a wide variety of biological functions including membrane embedded pores. Key influences of beta-barrel lumen diameter include the number of beta-strands (n) and the degree of shear (S), the latter value measuring the extent to which the beta-sheet is tilted within the beta-barrel. Notably, it has previously been reported that the shear value for small antiparallel beta-barrels (n 24 beta-strands). Giant beta-barrels can thus access a different architecture compared to smaller beta-barrels. CONTACT: Michelle.firstname.lastname@example.org SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.