Predictable αβ T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope

Rebekah M. Brennan, John J. Miles, Sharon L. Silins, Melissa J. Bell, Jacqueline M. Burrows, Scott R. Burrows

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Human cytomegalovirus (HCMV) elicits a very large burden on the immune system, with approximately one in ten T cells being reserved solely to manage this infection. However, information on the clonotypic composition of these vast T-cell populations is limited. In this study, we sequenced 116 T-cell receptor (TcR) α/β-chains specific for the highly immunogenic HLA-B*3501-resticted epitope IPSINVHHY from the pp65 antigen. Interestingly, T cells recovered from all donors bore an identical or near-identical TRBV28/TRBJ1-4/TRAV17/TRAJ33 TcR. The ability to predict the responding αβ TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology.

Original languageEnglish
Pages (from-to)7269-7273
Number of pages5
JournalJournal of Virology
Volume81
Issue number13
DOIs
Publication statusPublished - 1 Jul 2007
Externally publishedYes

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