Abstract
Human cytomegalovirus (HCMV) elicits a very large burden on the immune system, with approximately one in ten T cells being reserved solely to manage this infection. However, information on the clonotypic composition of these vast T-cell populations is limited. In this study, we sequenced 116 T-cell receptor (TcR) α/β-chains specific for the highly immunogenic HLA-B*3501-resticted epitope IPSINVHHY from the pp65 antigen. Interestingly, T cells recovered from all donors bore an identical or near-identical TRBV28/TRBJ1-4/TRAV17/TRAJ33 TcR. The ability to predict the responding αβ TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology.
Original language | English |
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Pages (from-to) | 7269-7273 |
Number of pages | 5 |
Journal | Journal of Virology |
Volume | 81 |
Issue number | 13 |
DOIs | |
Publication status | Published - 1 Jul 2007 |
Externally published | Yes |