Preclinical models for the study of Barrett's carcinogenesis

Matthew D. Read, Kausilia K. Krishnadath, Nicholas J. Clemons, Wayne A. Phillips

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Barrett's esophagus (BE) is clinically significant, as it is the only known precursor lesion for esophageal adenocarcinoma. To develop improved therapies for the treatment of BE, a greater understanding of the disease process at the molecular genetic level is needed. However, achieving a greater understanding will require improved preclinical models so that the disease process can be more closely studied and novel therapies can be tested. Our concise review highlights progress in the development of preclinical models for the study of BE and identifies the most suitable model in which to test novel therapies.

Original languageEnglish
Pages (from-to)139-148
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1434
Issue number1
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

Keywords

  • Animal models
  • Barrett's esophagus
  • Organoid
  • Preclinical model
  • Reflux models
  • Transgenic models

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