Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio; Saskia Reibe; Shabnam Shalapour; Geraldine J. Ooi; Matthew J. Watt; Michael Karin

doi:10.1016/j.cmet.2018.10.012

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio
, Saskia Reibe
, Shabnam Shalapour
, Geraldine J. Ooi
, Matthew J. Watt
, Michael Karin

Drug Discovery Biology

Research output: Contribution to journal › Review Article › Research › peer-review

219 Citations (Scopus)

Abstract

Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

Original language	English
Pages (from-to)	18-26
Number of pages	9
Journal	Cell Metabolism
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2018.10.012
Publication status	Published - 8 Jan 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

fatty liver
hepatocellular carcinoma
mouse models
non-alcoholic steatohepatitis
obesity
RNA-seq

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10.1016/j.cmet.2018.10.012

Cite this

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title = "Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?",

abstract = "Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.",

keywords = "fatty liver, hepatocellular carcinoma, mouse models, non-alcoholic steatohepatitis, obesity, RNA-seq",

author = "Febbraio, \{Mark A.\} and Saskia Reibe and Shabnam Shalapour and Ooi, \{Geraldine J.\} and Watt, \{Matthew J.\} and Michael Karin",

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journal = "Cell Metabolism",

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T1 - Preclinical Models for Studying NASH-Driven HCC

T2 - How Useful Are They?

AU - Febbraio, Mark A.

AU - Reibe, Saskia

AU - Shalapour, Shabnam

AU - Ooi, Geraldine J.

AU - Watt, Matthew J.

AU - Karin, Michael

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

AB - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

KW - fatty liver

KW - hepatocellular carcinoma

KW - mouse models

KW - non-alcoholic steatohepatitis

KW - obesity

KW - RNA-seq

UR - https://www.scopus.com/pages/publications/85058645580

U2 - 10.1016/j.cmet.2018.10.012

DO - 10.1016/j.cmet.2018.10.012

M3 - Review Article

C2 - 30449681

AN - SCOPUS:85058645580

SN - 1550-4131

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EP - 26

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Cite this

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Projects

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Cite this