Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio, Saskia Reibe, Shabnam Shalapour, Geraldine J. Ooi, Matthew J. Watt, Michael Karin

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalCell Metabolism
Volume29
Issue number1
DOIs
Publication statusPublished - 8 Jan 2019

Keywords

  • fatty liver
  • hepatocellular carcinoma
  • mouse models
  • non-alcoholic steatohepatitis
  • obesity
  • RNA-seq

Cite this

Febbraio, Mark A. ; Reibe, Saskia ; Shalapour, Shabnam ; Ooi, Geraldine J. ; Watt, Matthew J. ; Karin, Michael. / Preclinical Models for Studying NASH-Driven HCC : How Useful Are They?. In: Cell Metabolism. 2019 ; Vol. 29, No. 1. pp. 18-26.
@article{00690fcc199e4d8b8bb0655ab8ed93fd,
title = "Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?",
abstract = "Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.",
keywords = "fatty liver, hepatocellular carcinoma, mouse models, non-alcoholic steatohepatitis, obesity, RNA-seq",
author = "Febbraio, {Mark A.} and Saskia Reibe and Shabnam Shalapour and Ooi, {Geraldine J.} and Watt, {Matthew J.} and Michael Karin",
year = "2019",
month = "1",
day = "8",
doi = "10.1016/j.cmet.2018.10.012",
language = "English",
volume = "29",
pages = "18--26",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Elsevier",
number = "1",

}

Preclinical Models for Studying NASH-Driven HCC : How Useful Are They? / Febbraio, Mark A.; Reibe, Saskia; Shalapour, Shabnam; Ooi, Geraldine J.; Watt, Matthew J.; Karin, Michael.

In: Cell Metabolism, Vol. 29, No. 1, 08.01.2019, p. 18-26.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Preclinical Models for Studying NASH-Driven HCC

T2 - How Useful Are They?

AU - Febbraio, Mark A.

AU - Reibe, Saskia

AU - Shalapour, Shabnam

AU - Ooi, Geraldine J.

AU - Watt, Matthew J.

AU - Karin, Michael

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

AB - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

KW - fatty liver

KW - hepatocellular carcinoma

KW - mouse models

KW - non-alcoholic steatohepatitis

KW - obesity

KW - RNA-seq

UR - http://www.scopus.com/inward/record.url?scp=85058645580&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2018.10.012

DO - 10.1016/j.cmet.2018.10.012

M3 - Review Article

VL - 29

SP - 18

EP - 26

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 1

ER -