Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.
- fatty liver
- hepatocellular carcinoma
- mouse models
- non-alcoholic steatohepatitis