Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio; Saskia Reibe; Shabnam Shalapour; Geraldine J. Ooi; Matthew J. Watt; Michael Karin

doi:10.1016/j.cmet.2018.10.012

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio, Saskia Reibe, Shabnam Shalapour, Geraldine J. Ooi, Matthew J. Watt, Michael Karin

Research output: Contribution to journal › Review Article › Research › peer-review

115 Citations (Scopus)

Abstract

Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

Original language	English
Pages (from-to)	18-26
Number of pages	9
Journal	Cell Metabolism
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.cmet.2018.10.012
Publication status	Published - 8 Jan 2019

Keywords

fatty liver
hepatocellular carcinoma
mouse models
non-alcoholic steatohepatitis
obesity
RNA-seq

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2018.10.012

Cite this

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title = "Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?",

abstract = "Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.",

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author = "Febbraio, {Mark A.} and Saskia Reibe and Shabnam Shalapour and Ooi, {Geraldine J.} and Watt, {Matthew J.} and Michael Karin",

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T2 - How Useful Are They?

AU - Febbraio, Mark A.

AU - Reibe, Saskia

AU - Shalapour, Shabnam

AU - Ooi, Geraldine J.

AU - Watt, Matthew J.

AU - Karin, Michael

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

AB - Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

KW - fatty liver

KW - hepatocellular carcinoma

KW - mouse models

KW - non-alcoholic steatohepatitis

KW - obesity

KW - RNA-seq

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U2 - 10.1016/j.cmet.2018.10.012

DO - 10.1016/j.cmet.2018.10.012

M3 - Review Article

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JF - Cell Metabolism

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Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Cite this

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Towards a better understanding of the health benefits of physical activity: designing exercise mimetic for the treatment of disease

Cite this