Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

Mark A. Febbraio, Saskia Reibe, Shabnam Shalapour, Geraldine J. Ooi, Matthew J. Watt, Michael Karin

Research output: Contribution to journalReview ArticleResearchpeer-review

163 Citations (Scopus)


Progress in the understanding of NASH-driven HCC depends on reliable preclinical models that are amenable to genetic and functional analyses and exhibit robust NASH-to-HCC progression. We review current literature on molecular etiology of NASH-related HCC, and critically evaluate existing mouse models and their suitability for studying this malignancy.

Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalCell Metabolism
Issue number1
Publication statusPublished - 8 Jan 2019


  • fatty liver
  • hepatocellular carcinoma
  • mouse models
  • non-alcoholic steatohepatitis
  • obesity
  • RNA-seq

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