Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease

Katherine A. Morgan, Michael de Veer, Luke A. Miles, Cormac A.A. Kelderman, Catriona A. McLean, Colin L. Masters, Kevin J. Barnham, Jonathan M. White, Brett M. Paterson, Paul S. Donnelly

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

With the aim of developing the concept of pretargeted click chemistry for the diagnosis of Alzheimer's disease two antibodies specific for amyloid-β were modified to incorporate trans-cyclooctene functional groups. Two bis(thiosemicarbazone) compounds with pendant 1,2,4,5-tetrazine functional groups were prepared and radiolabelled with positron emitting copper-64. The new copper-64 complexes rapidly react with the trans-cyclooctene functionalized antibodies in a bioorthogonal click reaction and cross the blood-brain barrier in mice.

Original languageEnglish
Pages (from-to)2243-2246
Number of pages4
JournalChemical Communications
Volume59
Issue number16
DOIs
Publication statusPublished - 17 Jan 2023

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