Practical copper-catalyzed N-arylation of nitrogen heterocycles with aryl halides under ligand and additive free conditions

Joyce Wei Wei Chang; Xiuhui Xu; Philip Wai Hong Chan

doi:10.1016/j.tetlet.2006.11.050

Practical copper-catalyzed N-arylation of nitrogen heterocycles with aryl halides under ligand and additive free conditions

Joyce Wei Wei Chang, Xiuhui Xu, Philip Wai Hong Chan

Research output: Contribution to journal › Article › Research › peer-review

68 Citations (Scopus)

Abstract

N-arylation of a wide variety of nitrogen heterocycles with aryl iodides catalyzed by copper iodide under mild ligand and additive free conditions (ⁿBu₄NBr, PhMe, NaOH, reflux, 22 h) was accomplished in good to excellent yields (up to 95%) and substrate conversions (up to 99%).

Original language	English
Pages (from-to)	245-248
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/j.tetlet.2006.11.050
Publication status	Published - 8 Jan 2007
Externally published	Yes

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10.1016/j.tetlet.2006.11.050

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Cite this

Chang, J. W. W., Xu, X., & Chan, P. W. H. (2007). Practical copper-catalyzed N-arylation of nitrogen heterocycles with aryl halides under ligand and additive free conditions. Tetrahedron Letters, 48(2), 245-248. https://doi.org/10.1016/j.tetlet.2006.11.050

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