Practical copper-catalyzed N-arylation of nitrogen heterocycles with aryl halides under ligand and additive free conditions

Joyce Wei Wei Chang, Xiuhui Xu, Philip Wai Hong Chan

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68 Citations (Scopus)

Abstract

N-arylation of a wide variety of nitrogen heterocycles with aryl iodides catalyzed by copper iodide under mild ligand and additive free conditions (nBu4NBr, PhMe, NaOH, reflux, 22 h) was accomplished in good to excellent yields (up to 95%) and substrate conversions (up to 99%).

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number2
DOIs
Publication statusPublished - 8 Jan 2007
Externally publishedYes

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