TY - JOUR
T1 - Practical Considerations for Ketogenic Diet in Adults With Super-Refractory Status Epilepticus
AU - Kaul, Neha
AU - Laing, Joshua Andrew
AU - Nicolo, John-Paul
AU - Nation, Judy
AU - Kwan, Patrick
AU - O'Brien, Terence John
N1 - Funding Information:
N. Kaul and J. Laing are supported by Postgraduate Research Scholarships provided by the National Health and Medical Research Council. J.-P. Nicolo reports no disclosures relevant to the manuscript. J. Nation is employed by Vitaflo Australia Pty Ltd. P. Kwan is supported by a Medical Research Future Fund Practitioner Fellowship. T.J. O'Brien has received research grant funding from the Australian Government NHMRC and the US Government NINDS; he has also received commercial clinical trial funding from Eisai, UCB, Zynerba, Anavex, and Biogen Pharma. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp .
Publisher Copyright:
© 2022 American Academy of Neurology.
PY - 2021/10
Y1 - 2021/10
N2 - Purpose of ReviewKetogenic diet therapy can be used as an adjuvant treatment of super-refractory status epilepticus (SRSE). However, the drug and metabolic interactions with concomitant treatments present a challenge for clinicians. In this review, we focus on the practical considerations of implementing ketogenic dietary therapy in the acute setting, including the dietary composition, potential drug-diet interactions, and monitoring during ketogenic treatment.Recent FindingsThis report describes the ketogenic diet therapy protocol implemented for the treatment of SRSE and a review of the current evidence to support clinical practice.SummaryThe control of SRSE is critical in reducing morbidity and mortality. There is emerging evidence that ketogenic diet may be a safe and effective treatment option for these patients.
AB - Purpose of ReviewKetogenic diet therapy can be used as an adjuvant treatment of super-refractory status epilepticus (SRSE). However, the drug and metabolic interactions with concomitant treatments present a challenge for clinicians. In this review, we focus on the practical considerations of implementing ketogenic dietary therapy in the acute setting, including the dietary composition, potential drug-diet interactions, and monitoring during ketogenic treatment.Recent FindingsThis report describes the ketogenic diet therapy protocol implemented for the treatment of SRSE and a review of the current evidence to support clinical practice.SummaryThe control of SRSE is critical in reducing morbidity and mortality. There is emerging evidence that ketogenic diet may be a safe and effective treatment option for these patients.
UR - http://www.scopus.com/inward/record.url?scp=85131174609&partnerID=8YFLogxK
U2 - 10.1212/CPJ.0000000000001009
DO - 10.1212/CPJ.0000000000001009
M3 - Review Article
C2 - 34840870
AN - SCOPUS:85131174609
SN - 2163-0402
VL - 11
SP - 438
EP - 444
JO - Neurology: Clinical Practice
JF - Neurology: Clinical Practice
IS - 5
ER -