Powder strength distributions for understanding de-agglomeration of lactose powders

Shyamal Chandra Das, Srinivas Ravindra Babu Behara, Jurgen Bernd Bulitta, David Alexander Vodden Morton, Ian Clair Larson, Peter James Stewart

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Both active pharmaceutical ingredients (API) and ternary components such as lactose, commonly used in dry powder inhaler (DPI) formulations, are micron-sized and form cohesive matrices due to interparticulate interactions. In powder mixtures, these cohesive structures may be complex depending on the propensity of the cohesive-adhesive interactions of the materials. The de-agglomeration and aerosolization of these cohesive matrices are essential for effective delivery to the lower respiratory tract, the principal target of most respiratory drug delivery treatment. Although the target particle size of de-agglomerated powders is determined by the utilization purpose, it should be less than 5 I?m for deposition in the lower respiratory tract. The factors influencing the complex de-agglomeration process have been a focus of research for better formulation design.
Original languageEnglish
Pages (from-to)2926 - 2935
Number of pages10
JournalPharmaceutical Research
Volume29
Issue number10
DOIs
Publication statusPublished - 2012

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