Potential roles of the prokineticins in reproduction

David Maldonado-Pérez, Jemma Evans, Fiona Denison, Robert P. Millar, Henry N. Jabbour

Research output: Contribution to journalReview ArticleResearchpeer-review

82 Citations (Scopus)

Abstract

Prokineticins are multifunctional secreted proteins that were originally identified as regulators of intestinal contraction but subsequently shown to affect vascular function, hyperalgesia, spermatogenesis, neuronal survival, circadian rhythm, nociception, feeding behaviour, immune responses, haematopoiesis and the development of the olfactory and gonadotropin-releasing hormone systems. Their role in the reproductive tract is still not fully elucidated, although they are reputed to increase microvascular permeability. Expression of prokineticins and their receptors has been reported in the ovary, uterus, placenta, testis and prostate. Their expression has also been reported in various pathologies of the reproductive tract, and future studies will highlight whether inhibition of prokineticin function in these pathologies would be a useful therapeutic target.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume18
Issue number2
DOIs
Publication statusPublished - 1 Mar 2007

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