Potential of anthocyanin to prevent cardiovascular disease in diabetes

Almottesembellah Gaiz, Sapha Mosawy, Natalie Colson, Indu Singh

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)


Context Type 2 diabetes mellitus is an independent precipitating factor for cardiovascular disease (CVD). Heart disease is one of the leading causes of mortality in patients with diabetes, mainly due to macrovascular complications, such as atherosclerosis. Although aspirin is a frequently used therapy for the inhibition of platelet hyperactivity, many studies suggest that aspirin resistance is rising. Objective The study intended to investigate the benefits of anthocyanin (AC) as an antioxidant with inhibitory effects on platelets and, consequently, its potential usefulness as complementary antiplatelet therapy to attenuate the negative effects of atherosclerosis and CVD in patients with diabetes. Design The research team performed a literature review. The team conducted a database search from 2007 to 2017 using Library of Congress, LISTA, PubMed, and Web of Science Core Collection databases, using the following Setting The study took place at the School of Medical Sciences at Griffith University’s Gold Coast campus (Southport, Australia). Results Platelets have a major pathophysiological role of atherosclerosis and consequently CVD in diabetes. Antiplatelet drugs have a potent inhibitory effect of thrombotic and CVD risks in diabetes. Dietary antioxidants including ACs have a potential platelet inhibitory effect. Hence, ACs may act as complementary therapy to reduce CVD in diabetes. Conclusions Although antiplatelet drugs such as aspirin provide significant action in the management of CVD, aspirin has limited benefits in diabetes. An AC antioxidant has a potential effect as an antiplatelet agent that subsequently can prevent atherosclerosis and CVD and, therefore, AC may be an alternative to other antiplatelet drugs such as aspirin. However, more interventional studies and large-scale clinical trials are necessary to prove the efficiency of AC as an alternative to other platelet-inhibitory drugs.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalAlternative Therapies in Health and Medicine
Issue number3
Publication statusPublished - May 2018
Externally publishedYes


  • And diabetes
  • Anthocyanins
  • Cardiovascular disease
  • Platelet

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