TY - JOUR
T1 - Potential gut–brain mechanisms behind adverse mental health outcomes of bariatric surgery
AU - Brown, Robyn M.
AU - Guerrero-Hreins, Eva
AU - Brown, Wendy A.
AU - le Roux, Carel W.
AU - Sumithran, Priya
N1 - Funding Information:
C.W.l.R. reports grants from Science Foundation Ireland and grants from Health Research Board during the conduct of the study; other from Novo Nordisk and GI Dynamics, personal fees from Eli Lilly, grants and personal fees from Johnson and Johnson, personal fees from Sanofi Aventis, Astra Zeneca, Janssen, Bristol-Myers Squibb and Boehringer-Ingelheim outside the submitted work. P.S. reports personal fees from Novo Nordisk outside the submitted work. The other authors declare no competing interests.
Funding Information:
This manuscript received no external funding. R.M.B. acknowledges the support of an ARC DECRA Fellowship (DE190101244). P.S. acknowledges the support of a National Health and Medical Research Council Investigator Grant (1178482). We acknowledge the numerous researchers whose work we were unable to cite due to space limitations.
Publisher Copyright:
© 2021, Springer Nature Limited.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/9
Y1 - 2021/9
N2 - Bariatric surgery induces sustained weight loss and metabolic benefits via notable effects on the gut–brain axis that lead to alterations in the neuroendocrine regulation of appetite and glycaemia. However, in a subset of patients, bariatric surgery is associated with adverse effects on mental health, including increased risk of suicide or self-harm as well as the emergence of depression and substance use disorders. The contributing factors behind these adverse effects are not well understood. Accumulating evidence indicates that there are important links between gut-derived hormones, microbial and bile acid profiles, and disorders of mood and substance use, which warrant further exploration in the context of changes in gut–brain signalling after bariatric surgery. Understanding the basis of these adverse effects is essential in order to optimize the health and well-being of people undergoing treatment for obesity.
AB - Bariatric surgery induces sustained weight loss and metabolic benefits via notable effects on the gut–brain axis that lead to alterations in the neuroendocrine regulation of appetite and glycaemia. However, in a subset of patients, bariatric surgery is associated with adverse effects on mental health, including increased risk of suicide or self-harm as well as the emergence of depression and substance use disorders. The contributing factors behind these adverse effects are not well understood. Accumulating evidence indicates that there are important links between gut-derived hormones, microbial and bile acid profiles, and disorders of mood and substance use, which warrant further exploration in the context of changes in gut–brain signalling after bariatric surgery. Understanding the basis of these adverse effects is essential in order to optimize the health and well-being of people undergoing treatment for obesity.
UR - https://www.scopus.com/pages/publications/85112095607
U2 - 10.1038/s41574-021-00520-2
DO - 10.1038/s41574-021-00520-2
M3 - Review Article
C2 - 34262156
AN - SCOPUS:85112095607
SN - 1759-5029
VL - 17
SP - 549
EP - 559
JO - Nature Reviews Endocrinology
JF - Nature Reviews Endocrinology
IS - 9
ER -
SDG 3 Good Health and Well-being