Potential action of Rumex vesicarius (L.) against potassium dichromate and gentamicin induced nephrotoxicity in experimental rats

Vetriselvan Subramaniyan, Summaiya Shaik, Anupam Bag, Gobinath Manavalan, Sarath Chandiran

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14 Citations (Scopus)

Abstract

To determine the ameliorative potential of the active fraction from different extracts of Rumex vesicarius against potassium dichromate and gentamicin induced nephrotoxicity in experimental rats and its possible mechanism of action. Both sex wistar rats were divided into 6 groups (n=6/group) were fed with a control, potassium dichromate and gentamicin supplemented with different extracts at the doses of 200 and 400mg/kg respectively. Oral administration of EERV offered a significant (P<0.01 and P<0.001) dose dependent protection against PD and GN induced nephrotoxicity. Potassium dichromate and gentamicin nephrotoxicity assessed in terms of body weight, kidney weight, creatinine, urea, uric acid, BUN, albumin and total protein. Thus the present study revealed that EERV phytochemical constituents play an important role in protection against kidney damage.

Original languageEnglish
Pages (from-to)509-516
Number of pages8
JournalPakistan Journal of Pharmaceutical Sciences
Volume31
Issue number2
Publication statusPublished - Mar 2018
Externally publishedYes

Keywords

  • Gentamicin
  • Kidney protection
  • Nephrotoxicity
  • Potassium dichromate
  • Rumex vesicarius
  • Serum markers

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