Potent PPARy ligands from Swietenia macrophylla are capable of stimulating glucose uptake in muscle cells

Wai Kwan Lau, Bey Hing Goh, Habsah Abdul Kadir, Alexander Shu-Chien Chong, Tengku Sifzizul Tengku Muhammad

    Research output: Contribution to journalArticleResearchpeer-review

    12 Citations (Scopus)

    Abstract

    Numerous documented ethnopharmacological properties have been associated with Swietenia macrophylla (Meliaceae), with its seed extract reported to display anti-hypoglycemic activities in diabetic rats. In the present study, three compounds isolated from the seeds of S. macrophylla were tested on a modified ELISA binding assay and showed to possess PPARy ligand activity. They were corresponded to PPARy-mediated cellular response, stimulated adipocyte differentiation but produced lower amount of fat droplets compared to a conventional anti-diabetic agent, rosiglitazone. The up-regulation of adipocytes was followed by increased adipocyte-related gene expressions such as adiponectin, adipsin, and PPARy. The S. macrophylla compounds also promoted cellular glucose uptake via the translocation of GLUT4 glucose transporter.
    Original languageEnglish
    Pages (from-to)22301 - 22314
    Number of pages14
    JournalMolecules
    Volume20
    Issue number12
    DOIs
    Publication statusPublished - 2015

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