Postural Sway Characteristics Are Affected by Alzheimer's Disease

Mehrangiz Ashiri, Cristina Francisco, Jeffrey Winkler, Brian Lithgow, Zahra Moussavi

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

The vestibular system, responsible for balance, is affected by Alzheimer's disease (AD). In this paper, linear and non-linear balance features were used to assess the postural stability of 13 AD individuals at mild stages in comparison with 16 healthy controls. Utilizing two accelerometers, the anterior-posterior (AP) and medial-lateral (ML) sways were recorded from the T2 vertebrae and lateral malleolus of participants standing on a solid and soft foam surface under both eyes-open and eyes-closed conditions. From the recorded signals, four features were extracted and used for statistical analysis: Number of Position Changes (NPC), Number of Non-Zero Accelerations (NNZA), Katz, and Higuchi fractal dimensions (KFD and HFD, respectively). The results show: 1) postural stability is significantly worse for the eyes-closed compared to eyes-open condition (P<0.05 for all features except HFD) as well as whilst standing on soft foam compared to the solid surface (P<0.05 for all features) in both groups; 2) balance perturbations were larger for AP sway than ML on both solid and foam surfaces in both groups (P<0.05 for NPC and NNZA); and 3) stationary balance is significantly poorer for AD individuals compared to controls (P<0.05 for all features). These observations show that both linear and non-linear characteristics of postural stability data have the potentials to be used as objective diagnostic aids for the detection of AD.

Original languageEnglish
Title of host publication43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society
EditorsJoaquin Azpiroz, Roberto Lavarello
Place of PublicationPiscataway NJ USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages7219-7222
Number of pages4
ISBN (Electronic)9781728111797, 9781728111780
ISBN (Print)9781728111803
DOIs
Publication statusPublished - 2021
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2021 - Online, Mexico
Duration: 1 Nov 20215 Nov 2021
Conference number: 43rd
https://embc.embs.org/2021/ (Website)
https://ieeexplore-ieee-org.ezproxy.lib.monash.edu.au/xpl/conhome/9629355/proceeding (Proceedings)

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
Publisher IEEE, Institute of Electrical and Electronics Engineers
ISSN (Print)2375-7477
ISSN (Electronic)2694-0604

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2021
Abbreviated titleEMBC 2021
Country/TerritoryMexico
CityOnline
Period1/11/215/11/21
Internet address

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